Cancer stem cells

Definition

Cancer stem cells are rare immortal cells within a tumour that can both self-renew by dividing and give rise to many cell types that constitute the tumour, and can therefore form tumours. Such cells have been found in various types of human tumours and might be attractive targets for cancer treatment.

Latest Research and Reviews

  • Research |

    Celià-Terrassa et al. find that by repressing LCOR, a modulator of the interferon response, miR-199a allows both normal and cancer mammary stem cells to evade senescence and differentiation, thus promoting tumorigenesis.

    • Toni Celià-Terrassa
    • , Daniel D. Liu
    • , Abrar Choudhury
    • , Xiang Hang
    • , Yong Wei
    • , Jose Zamalloa
    • , Raymundo Alfaro-Aco
    • , Rumela Chakrabarti
    • , Yi-Zhou Jiang
    • , Bong Ihn Koh
    • , Heath A. Smith
    • , Christina DeCoste
    • , Jun-Jing Li
    • , Zhi-Ming Shao
    •  & Yibin Kang
  • Research |

    Cancer stem cells are typically refractory to conventional treatments. Now, an unprecedented mechanism has been discovered by which salinomycin and derivatives can sequester iron in lysosomes leading to cytoplasmic iron depletion and the subsequent production of reactive oxygen species that are lethal to the cell. This discovery of the importance of iron in cancer stem cell maintenance provides an opportunity for developing new therapeutics.

    • Trang Thi Mai
    • , Ahmed Hamaï
    • , Antje Hienzsch
    • , Tatiana Cañeque
    • , Sebastian Müller
    • , Julien Wicinski
    • , Olivier Cabaud
    • , Christine Leroy
    • , Amandine David
    • , Verónica Acevedo
    • , Akihide Ryo
    • , Christophe Ginestier
    • , Daniel Birnbaum
    • , Emmanuelle Charafe-Jauffret
    • , Patrice Codogno
    • , Maryam Mehrpour
    •  & Raphaël Rodriguez
  • Research | | open

    While the role of ASLX1 in haematopoiesis and leukaemia has been heavily studied, the role of ASLX2 is unclear. Here the authors show that ASLX2 is required for normal haematopoietic stem cell self-renewal whereas Asxl2 loss promotes leukemogenesis, thus explaining the frequently observed mutations in AML patients

    • Jean-Baptiste Micol
    • , Alessandro Pastore
    • , Daichi Inoue
    • , Nicolas Duployez
    • , Eunhee Kim
    • , Stanley Chun-Wei Lee
    • , Benjamin H. Durham
    • , Young Rock Chung
    • , Hana Cho
    • , Xiao Jing Zhang
    • , Akihide Yoshimi
    • , Andrei Krivtsov
    • , Richard Koche
    • , Eric Solary
    • , Amit Sinha
    • , Claude Preudhomme
    •  & Omar Abdel-Wahab
  • Research |

    Applying a new, more sensitive single-cell transcriptomics method to diagnosis, remission and progression samples from patients with chronic myeloid leukemia reveals insight into the heterogeneity of cells that resist treatment with targeted therapy, as well as into the dynamics of disease progression and its effects on nontransformed hematopoietic stem cells.

    • Alice Giustacchini
    • , Supat Thongjuea
    • , Nikolaos Barkas
    • , Petter S Woll
    • , Benjamin J Povinelli
    • , Christopher A G Booth
    • , Paul Sopp
    • , Ruggiero Norfo
    • , Alba Rodriguez-Meira
    • , Neil Ashley
    • , Lauren Jamieson
    • , Paresh Vyas
    • , Kristina Anderson
    • , Åsa Segerstolpe
    • , Hong Qian
    • , Ulla Olsson-Strömberg
    • , Satu Mustjoki
    • , Rickard Sandberg
    • , Sten Eirik W Jacobsen
    •  & Adam J Mead

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