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Understanding tissue context influences on intratumour heterogeneity

Nature Cell Biology volume 16, pages 301–302 (2014)Cite this article

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Although human cancers exhibit intratumour heterogeneity, the influence of the tumour environment on this property is unclear. Single basal-like mammary epithelial cells are now shown to engage a dynamic TGFBR3–JUND signalling circuit in an extracellular-matrix-dependent manner. Cell transition between the distinct gene expression states underlying this circuit alters their properties and may modulate their propensity to malignancy.

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Figure 1: Tissue context and intratumour heterogeneity.

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Acknowledgements

We would like to thank Vanessa Almendro for assistance with the figure.

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Authors and Affiliations

  1. Franziska Michor is in the Department of Biostatistics and Computational Biology, and Department of Biostatistics, Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, Massachusetts 02215, USA,

    Franziska Michor

  2. Valerie M. Weaver is at the Center for Bioengineering and Tissue Regeneration and Departments of Surgery, Anatomy, Bioengineering and Therapeutics, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and Helen Diller Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA,

    Valerie M. Weaver

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  1. Franziska Michor
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Correspondence to Franziska Michor or Valerie M. Weaver.

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Michor, F., Weaver, V. Understanding tissue context influences on intratumour heterogeneity. Nat Cell Biol 16, 301–302 (2014). https://doi.org/10.1038/ncb2942

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