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Both naive and memory B cells respond to flu vaccine

Influenza vaccination induces a protective memory immune response. The finding that human naive and memory B cells enter vaccine-induced germinal-centre structures suggests that both cell types aid this memory response.
  1. Lauren B. Rodda

    1. Lauren B. Rodda is in the Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98109, USA.

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  2. Marion Pepper

    1. Marion Pepper isin the Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98109, USA.

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Between yearly vaccinations and seasonal infections, people repeatedly mount an immune response against the influenza virus. A flu vaccination is recommended each year to aid the body’s ability to fight the latest flu strain in circulation. To improve the effectiveness of vaccination, researchers need to understand how this immunological history affects the immune memory induced by each subsequent flu vaccination. Writing in Nature, Turner et al.1 investigate the human immune response to seasonal-flu vaccination, and report direct data on which of the various types of an immune cell called a B cell participates in events in highly organized structures called germinal centres. These events are crucial for the process by which immune cells join and diversify the pool of cells that form what is termed the immune-memory compartment.

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Nature 586, 34-35 (2020)

doi: https://doi.org/10.1038/d41586-020-02556-2

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