The HBx protein of hepatitis B virus has been found to co-opt a host-cell enzyme that targets the Smc5/6 protein complex for degradation. The finding identifies Smc5/6 as a cellular antiviral factor. See Letter p.386
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Notes
References
Decorsière, A. et al. Nature 531, 386–389 (2016).
Zoulim, F., Saputelli, J. & Seeger, C. J. Virol. 68, 2026–2030 (1994).
Zhang, Z., Torii, N., Hu, Z., Jacob, J. & Liang, T. J. J. Clin. Invest. 108, 1523–1531 (2001).
Lee, T.-H., Elledge, S. J. & Butel, J. S. J. Virol. 69, 1107–1114 (1995).
Bosu, D. R. & Kipreos, E. T. Cell Div. 3, 7 (2008).
Randow, F. & Lehner, P. J. Nature Cell Biol. 11, 527–534 (2009).
Emanuele, M. J. et al. Cell 147, 459–474 (2011).
Tavalai, N. & Stamminger, T. Virus Res. 157, 128–133 (2011).
Wiebe, M. S. & Jamin, A. J. Virol. http://dx.doi.org/10.1128/JVI.00178-16 (2016).
Stenglein, M. D., Burns, M. B., Li, M., Lengyel, J. & Harris, R. S. Nature Struct. Mol. Biol. 17, 222–229 (2010).
Lucifora, J. et al. Science 343, 1221–1228 (2014).
Kegel, A. & Sjögren, C. Cold Spring Harb. Symp. Quant. Biol. 75, 179–187 (2010).
Levrero, M. et al. J. Hepatol. 51, 581–592 (2009).
Author information
Authors and Affiliations
Corresponding author
Related links
Rights and permissions
About this article
Cite this article
Liang, T. The X-Files of hepatitis B. Nature 531, 313–314 (2016). https://doi.org/10.1038/531313a
Published:
Issue Date:
DOI: https://doi.org/10.1038/531313a
This article is cited by
-
Analysis of fitness differences of hepatitis B virus genotypes D and F using a cotransfection assay
Archives of Virology (2019)