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Blindness

Assassins of eyesight

Nature volume 527, pages 456–457 (2015)Cite this article

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A molecular cascade involving the transcription factor SIX6 and its target gene p16INK4a causes the death of neurons that link the eye to the brain. This discovery deepens our understanding of a common form of blindness, glaucoma.

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Figure 1: Molecular pathways that underlie glaucoma.

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Author notes

  1. reldanaf@ucsd.edu

Authors and Affiliations

  1. Division of Biological Science, and in the Departments of Neurosciences and Ophthalmology, Andrew D. Huberman and Rana N. El-Danaf are in the Neurobiology Section, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA.,

    Andrew D. Huberman & Rana N. El-Danaf

  2. A.D.H. is also at the Salk Institute for Biological Studies, La Jolla.,

    Andrew D. Huberman

Authors
  1. Andrew D. Huberman
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  2. Rana N. El-Danaf
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Corresponding authors

Correspondence to Andrew D. Huberman or Rana N. El-Danaf.

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Huberman, A., El-Danaf, R. Assassins of eyesight. Nature 527, 456–457 (2015). https://doi.org/10.1038/527456a

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