The identification of a regulatory site on the UBE3A protein that can be phosphorylated to alter its enzymatic activity provides insight into the aetiology of two human neurodevelopmental diseases, Angelman syndrome and autism.
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Elgersma, Y. A molecular tightrope. Nature 526, 50–51 (2015). https://doi.org/10.1038/526050b
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DOI: https://doi.org/10.1038/526050b