Activation of the signalling molecule SHP2 is implicated in driving several cancers. In a newly described class of bone-progenitor cells, however, it seems that the protein acts as a tumour suppressor. See Letter p.491
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Notes
*This article and the paper under discussion1 were published online on 17 July.
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Zaidi, M., Méndez-Ferrer, S. Tumour stem cells in bone. Nature 499, 414–416 (2013). https://doi.org/10.1038/nature12412
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DOI: https://doi.org/10.1038/nature12412