Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cell biology

Tumour stem cells in bone

Activation of the signalling molecule SHP2 is implicated in driving several cancers. In a newly described class of bone-progenitor cells, however, it seems that the protein acts as a tumour suppressor. See Letter p.491

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Regulation of chondrocyte formation.

Notes

  1. *This article and the paper under discussion1 were published online on 17 July.

References

  1. Yang, W. et al. Nature 499, 491–495 (2013).

    Article  ADS  CAS  Google Scholar 

  2. Maes, C. et al. Dev. Cell 19, 329–344 (2010).

    Article  CAS  Google Scholar 

  3. Zaidi, M. Nature Med. 13, 791–801 (2007).

    Article  CAS  Google Scholar 

  4. Bowen, M. E. et al. PLoS Genet. 7, e1002050 (2011).

    Article  CAS  Google Scholar 

  5. Zaidi, M., Troen, B., Moonga, B. S. & Abe, E. J. Bone Miner. Res. 16, 1747–1749 (2001).

    Article  CAS  Google Scholar 

  6. Nakamura, T. et al. Cell 130, 811–823 (2007).

    Article  CAS  Google Scholar 

  7. Park, D. et al. Cell Stem Cell 10, 259–272 (2012).

    Article  CAS  Google Scholar 

  8. Zaidi, M., Sun, L. & Blair, H. C. Cell Stem Cell 10, 233–234 (2012).

    Article  CAS  Google Scholar 

  9. Mendez-Ferrer, S. et al. Nature 466, 829–834 (2010).

    Article  ADS  CAS  Google Scholar 

  10. Isern, J. et al. Cell Rep. 3, 1714–1724 (2013).

    Article  CAS  Google Scholar 

  11. Grossmann, K. S., Rosário, M., Birchmeier, C. & Birchmeier, W. Adv. Cancer Res. 106, 53–89 (2010).

    Article  CAS  Google Scholar 

  12. Kontaridis, M. I., Swanson, K. D., David, F. S., Barford, D. & Neel, B. G. J. Biol. Chem. 281, 6785–6792 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Mone Zaidi or Simón Méndez-Ferrer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zaidi, M., Méndez-Ferrer, S. Tumour stem cells in bone. Nature 499, 414–416 (2013). https://doi.org/10.1038/nature12412

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature12412

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer