Physiology

Definition

Physiology is the branch of the biological sciences that deals with the life-supporting functions and processes of living organisms or their parts. The study of physiology aims to understand how living things work, which can then aid the treatment of diseases.

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Latest Research and Reviews

  • Research |

    When faced with hypoxic conditions, Mycobacterium tuberculosis adapts its metabolism to generate intermediates reserved for re-initiation of peptidoglycan biosynthesis that can be used as soon as it is re-exposed to normoxia.

    • Hyungjin Eoh
    • , Zhe Wang
    • , Emilie Layre
    • , Poonam Rath
    • , Roxanne Morris
    • , D. Branch Moody
    •  & Kyu Y. Rhee
  • Research |

    Joanna Howson and colleagues perform a genome-wide association study and meta-analysis for coronary artery disease in large, trans-ancestry cohorts. They identify 15 new loci and correlate these regions with cell-type-specific gene expression and plasma protein levels to find novel pathways and potential mechanisms of disease.

    • Joanna M M Howson
    • , Wei Zhao
    • , Daniel R Barnes
    • , Weang-Kee Ho
    • , Robin Young
    • , Dirk S Paul
    • , Lindsay L Waite
    • , Daniel F Freitag
    • , Eric B Fauman
    • , Elias L Salfati
    • , Benjamin B Sun
    • , John D Eicher
    • , Andrew D Johnson
    • , Wayne H H Sheu
    • , Sune F Nielsen
    • , Wei-Yu Lin
    • , Praveen Surendran
    • , Anders Malarstig
    • , Jemma B Wilk
    • , Anne Tybjærg-Hansen
    • , Katrine L Rasmussen
    • , Pia R Kamstrup
    • , Panos Deloukas
    • , Jeanette Erdmann
    • , Sekar Kathiresan
    • , Nilesh J Samani
    • , Heribert Schunkert
    • , Hugh Watkins
    • , CARDIoGRAMplusC4D
    • , Ron Do
    • , Daniel J Rader
    • , Julie A Johnson
    • , Stanley L Hazen
    • , Arshed A Quyyumi
    • , John A Spertus
    • , Carl J Pepine
    • , Nora Franceschini
    • , Anne Justice
    • , Alex P Reiner
    • , Steven Buyske
    • , Lucia A Hindorff
    • , Cara L Carty
    • , Kari E North
    • , Charles Kooperberg
    • , Eric Boerwinkle
    • , Kristin Young
    • , Mariaelisa Graff
    • , Ulrike Peters
    • , Devin Absher
    • , Chao A Hsiung
    • , Wen-Jane Lee
    • , Kent D Taylor
    • , Ying-Hsiang Chen
    • , I-Te Lee
    • , Xiuqing Guo
    • , Ren-Hua Chung
    • , Yi-Jen Hung
    • , Jerome I Rotter
    • , Jyh-Ming J Juang
    • , Thomas Quertermous
    • , Tzung-Dau Wang
    • , Asif Rasheed
    • , Philippe Frossard
    • , Dewan S Alam
    • , Abdulla al Shafi Majumder
    • , Emanuele Di Angelantonio
    • , Rajiv Chowdhury
    • , EPIC-CVD
    • , Yii-Der Ida Chen
    • , Børge G Nordestgaard
    • , Themistocles L Assimes
    • , John Danesh
    • , Adam S Butterworth
    •  & Danish Saleheen
  • Research |

    Cecilia Lo and colleagues report the recovery of mice with hypoplastic left heart syndrome (HLHS) from a large mutagenesis screen. They find genetic heterogeneity among HLHS mice and functionally validate mutations in two genes, Sap130 and Pcdha, as contributing to HLHS in a combinatorial manner.

    • Xiaoqin Liu
    • , Hisato Yagi
    • , Shazina Saeed
    • , Abha S Bais
    • , George C Gabriel
    • , Zhaohan Chen
    • , Kevin A Peterson
    • , You Li
    • , Molly C Schwartz
    • , William T Reynolds
    • , Manush Saydmohammed
    • , Brian Gibbs
    • , Yijen Wu
    • , William Devine
    • , Bishwanath Chatterjee
    • , Nikolai T Klena
    • , Dennis Kostka
    • , Karen L de Mesy Bentley
    • , Madhavi K Ganapathiraju
    • , Phillip Dexheimer
    • , Linda Leatherbury
    • , Omar Khalifa
    • , Anchit Bhagat
    • , Maliha Zahid
    • , William Pu
    • , Simon Watkins
    • , Paul Grossfeld
    • , Stephen A Murray
    • , George A Porter Jr
    • , Michael Tsang
    • , Lisa J Martin
    • , D Woodrow Benson
    • , Bruce J Aronow
    •  & Cecilia W Lo
  • Research |

    Two studies by Sugden et al. and Jin et al. show that endoglin regulates endothelial cell migration through VEGFR2 signalling and controls blood vessel diameter in response to blood flow.

    • Wade W. Sugden
    • , Robert Meissner
    • , Tinri Aegerter-Wilmsen
    • , Roman Tsaryk
    • , Elvin V. Leonard
    • , Jeroen Bussmann
    • , Mailin J. Hamm
    • , Wiebke Herzog
    • , Yi Jin
    • , Lars Jakobsson
    • , Cornelia Denz
    •  & Arndt F. Siekmann
  • Research |

    A randomized clinical trial reveals that the antidiabetic effects of metformin are at least partially due to beneficial changes in the microbiota.

    • Hao Wu
    • , Eduardo Esteve
    • , Valentina Tremaroli
    • , Muhammad Tanweer Khan
    • , Robert Caesar
    • , Louise Mannerås-Holm
    • , Marcus Ståhlman
    • , Lisa M Olsson
    • , Matteo Serino
    • , Mercè Planas-Fèlix
    • , Gemma Xifra
    • , Josep M Mercader
    • , David Torrents
    • , Rémy Burcelin
    • , Wifredo Ricart
    • , Rosie Perkins
    • , José Manuel Fernàndez-Real
    •  & Fredrik Bäckhed

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