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Using a large US cohort of adolescents, the authors examine exposomic and polygenic contributions to allostatic load and a mediating role of allostatic load on the path from exposomic and polygenic risks to psychopathology.
ADHD is the most common neurodevelopmental disorder in children, yet despite a large increase in awareness and in the number of diagnoses, much less is known about how this disorder affects adults. More research is needed to understand how ADHD may present differently as a function of age or how the experience of ADHD may change in people as they age.
Authors present data supporting a neuropsychological pathway between emotion dysregulation and ADHD symptoms involving morphometry of the right pars orbitalis, transcriptomic, and white blood cell markers.
In this Review, the authors discuss the neurobiological mechanisms of motor cortex-related analgesia, drawing insights from both experimental data and clinical data.
Applying machine learning to an objective framework for suicidality, the authors demonstrate that four suicidal thought and behavior variables can be predicted with high accuracy and may present a scalable system for suicide risk assessment.
Increasing inequality and social fragmentation may give rise to a collective state of despair that may not only diminish the desire to live but also dampen the drive to reproduce, resulting in shrinking fertility and population decline.
The COVID-19 pandemic has caused profound mental health problems among left-behind children (LBC). Here we discuss the challenges that LBC are facing in the post-COVID-19 era and the potential underlying mechanisms, and provide recommendations for future policy priorities.
In this Perspective, authors argue for a more robust and comprehensive postmarket surveillance program of psychedelic-assisted psychotherapy to better ensure safe, appropriate and equitable care for patients.
In this Perspective, the authors make recommendations on better aligning stakeholders, including those in technology, practitioners and researchers, to increase collaboration and governance in technology and mental health.
In this study, the authors investigate the association between price inflation and mental health service uptake in the United Kingdom, demonstrating that increasing costs of living exacerbate mental health needs, particularly among adults and older populations.
In this prospective longitudinal study of alcohol consumption and patterns in heavy drinking young adults, significant reductions in alcohol use quantity, frequency and problems were observed from pre- to post-pandemic onset.
Analyzing national registry data, the authors use within-sibling design and two-sample Mendelian randomization to identify bidirectional causal relationships between educational attainment (EA) and mental health conditions, demonstrating that lower levels of EA were differentially associated with some disorders, such as major depressive disorder, but that attention-deficit/hyperactivity disorder causally affected EA.
Wade and colleagues analyze data from the Bucharest Early Intervention Project to examine whether stress reactivity measured at age 12 may serve as a mechanism linking early institutional deprivation with psychopathology at age 16.
This Review discusses the specific challenges and strategies in supporting individuals with ADHD during the critical transition to adulthood and outlines arguments for engaging and training parents.
Using task-based functional MRI, we examined inpatients with heroin use disorder. We found that 15 weeks of medication-assisted treatment (including supplemental group therapy) improved impaired anterior and dorsolateral prefrontal cortex function during an inhibitory control task. Inhibitory control, a core deficit in drug addiction, may be amenable to targeted prefrontal cortex interventions.
The authors examined the effect of psychosocial therapy, in addition to medication for heroin dependence, on inhibitory control brain activity and behavioral performance in individuals with heroin use disorder.