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Socioeconomic inequalities are antecedents for poor mental health outcomes. Mental illness is highly prevalent internationally — impacting 1 in 8 people, with incidence of anxiety and depression skyrocketing during the pandemic. In the USA, one of the world’s wealthiest nations, the economic outlook remains bleak.
The language of mental health is always being updated to better capture states of being and to be more inclusive. ‘Lived experience’, the core qualia of a mental health condition as it is perceived and inhabited by an individual, reflects this evolution. It is what makes some of us mental health ‘experts by experience’.
Moving the needle in mental health research requires doing justice to the social, psychological, biological and developmental complexities that affect people in their living environments. We developed a comprehensive national research program to achieve scale and depth through translational project bundles focused on early recognition and prevention, urban mental health, and enhanced psychotherapy, underpinned by a range of shared infrastructures. The program was consistently co-created with and will involve people with lived experience at all stages of research.
Tully et al. detected increased variability in brain total grey matter volume in individuals with disruptive behaviour disorder and antisocial personality disorder.
Seitz-Holland et al. examined the relationship between systemic cellular senescence markers and clinical variables in late-life depression. The authors find that signs of enhanced cellular senescence are associated with poor cardiometabolic health, older age, male sex and worse cognition.
Using data-driven disease-progression modelling, Jiang, Wang, Zhou et al. characterized and replicated two distinct ‘trajectories’ of brain atrophy in patients with schizophrenia.
Cash et al. examined whether coordinates derived from neuroimaging studies might delineate a dysfunctional brain network in unipolar depression rather than isolated neuroanatomical foci. The authors found highly robust distributed brain networks that closely recapitulate clinically meaningful models of depression circuitry.
We spoke to Thema S. Bryant — the 2023 president of the American Psychological Association (APA), academic, author, podcaster and pastor — about the many roles she has and her singular vision for more inclusive psychology.
February 2023 marks Black History Month in the USA. It is a tradition that was built on the grass-roots commemoration of the principles of tradition and reform established in Negro History Week in 1926 (ref. 1). In the 1960s, lifted by the Civil Rights Movement, it was expanded into a month-long celebration by activists, and on college campuses by students and faculty. Born out of a yearning to better recognize the achievements of Black people in America, Black History Month also speaks to the reality that these achievements have been gained in the face of enduring hardships and the inheritance of racism and oppression.
Will connectome-based predictive modeling change how we care for people at risk of late-life suicide? A novel two-step modeling approach used by Gao et al. in their study sheds light on the road ahead.
Adolescents differ in their beliefs, or mindsets, about the nature and workings of their personal qualities. Here we present theory and data that show why changing adolescents’ mindsets can lead to more productive coping with challenging situations and improved mental health.
Lee et al. combined data from mobile phone users, green spaces distribution and the United Kingdom Household Longitudinal Survey from 2020 to 2021 to evaluate how access to green spaces affected people’s mental health during COVID-19 pandemic lockdowns.
Lee et al. identify a positive relationship between life stress and current psychological symptoms in individuals with low, but not high, cortisol response and positive affectivity.
This Review summarizes the advances in personalized medicine and drug discovery in psychiatry and suggests a framework for the development of clinically relevant biological subtypes in the field.