Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
This Perspective describes the current state of point-of-care sensors for the diagnosis and monitoring of sepsis, and outlines opportunities for their use in improving the care of sepsis patients.
Intratumoral injection of a hydrogel impregnated with radioisotope-labelled catalase and an immunostimulant, along with systemic immune checkpoint blockade, inhibits tumour growth in mouse models of localized cancer and metastatic cancer.
Ultraflexible coils for magnetic resonance imaging enhance the image quality of body parts that move or that show strong inter-patient variability, as demonstrated by the implementation of the coils on a glove for imaging the moving hand.
Two drug-loaded nanoparticle formulations that preferentially accumulate within tumour-associated macrophages induce macrophage repolarization to a tumoricidal state that leads to potent antitumour activity in multiple murine models of cancer.
Design principles for the development of silicon biointerfaces enable the non-genetic, light-controlled modulation of intracellular Ca2+ dynamics, and of cellular excitability in vitro, in tissue slices and in mouse brains.
Biopolymer matrices can modulate the transcriptomic profiles of stem-cell-derived neurons in 3D culture to make them resemble cells in specific brain regions, developmental stages and disease conditions.
A technique combining focused ultrasound for opening the blood–brain barrier and virally encoded engineered G-protein-coupled receptors for promoting the expression of a gene targeting excitatory neurons enables the non-invasive stimulation of specific brain regions and cell types in mice.
Polymer-coated gold nanoparticles carrying the CRISPR components for knocking out, in the striatum of adult mice with fragile X syndrome, a gene implied in the syndrome’s pathophysiology rescue the mice from the exaggerated repetitive behaviours characteristic of the syndrome’s phenotype.
Nanoscale metal–organic frameworks carrying an immunotherapy payload and administered into tumours alongside a low dose of radiotherapy enhance local and systemic antitumour immunity in mouse models of breast cancer and colorectal cancer.
Heart tissue with an adult-like phenotype can be obtained by electromechanically conditioning, with increasing intensity, early-stage human induced pluripotent stem cells derived from cardiomyocytes.
A physiologically relevant microvasculature-on-a-chip device enables the study of microvascular pathology associated with inflammation and haematological diseases.
This Review discusses the manufacturing of cell products for clinically advanced cell therapies, and highlights potential manufacturing bottlenecks and solutions towards the cost-effective commercialization of the therapies.
This Review Article provides an overview of chimeric antigen receptors (CARs) for T cells and discusses engineering strategies for the design of next-generation CAR-T therapies for haematologic and solid cancers.
This Perspective provides an overview of recent cardiac cell therapies and their limitations, and argues for the need of deeper mechanistic understanding that informs the use of cells and of next-generation cell-free biologics in cardiac regeneration.
The sustained delivery of extracellular vesicles, secreted by induced-pluripotent-stem-cell-derived cardiomyocytes, through a hydrogel patch promotes cardiac recovery after myocardial infarction in rats.
