Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

ENGINEERED TISSUE

Training heart tissue to mature

Nature Biomedical Engineering volume 2, pages 351–352 (2018)Cite this article

Subjects

Heart tissue with an adult-like phenotype can be obtained by electromechanically conditioning, with increasing intensity, early-stage human induced pluripotent stem cells derived from cardiomyocytes.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Generation of mature engineered heart tissue from cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs).

References

  1. Hartman, M. E., Dai, D.-F. & Laflamme, M. A. Adv. Drug Deliv. Rev. 96, 3–17 (2016).

    Article  CAS  Google Scholar 

  2. Yang, X., Pabon, L. & Murry, C. E. Circ. Res. 114, 511–523 (2014).

    Article  CAS  Google Scholar 

  3. Lundy, S. D., Zhu, W.-Z., Regnier, M. & Laflamme, M. A. Stem Cells Dev. 22, 1991–2002 (2013).

    Article  CAS  Google Scholar 

  4. Yang, X. et al. J. Mol. Cell. Cardiol. 72, 296–304 (2014).

    Article  CAS  Google Scholar 

  5. Parikh, S. S. et al. Circ. Res. 121, 1323–1330 (2017).

    Article  CAS  Google Scholar 

  6. Herron, T. J. et al. Circ. Arrhythm. Electrophysiol. 9, e003638 (2016).

    Article  CAS  Google Scholar 

  7. Kuppusamy, K. T. et al. Proc. Natl Acad. Sci. USA 112, E2785–E2794 (2015).

    Article  CAS  Google Scholar 

  8. Nunes, S. S. et al. Nat. Methods 10, 781–787 (2013).

    Article  CAS  Google Scholar 

  9. Ruan, J.-L. et al. Circulation 134, 1557–1567 (2016).

    Article  CAS  Google Scholar 

  10. Jackman, C. P., Carlson, A. L. & Bursac, N. Biomaterials 111, 66–79 (2016).

    Article  CAS  Google Scholar 

  11. Tiburcy, M. et al. Circulation 135, 1832–1847 (2017).

    Article  CAS  Google Scholar 

  12. Zimmermann, W.-H., Tiburcy, M. & Eschenhagen, T. Future Cardiol. 3, 435–445 (2007).

    Article  CAS  Google Scholar 

  13. Gao, L. et al. Circulation 137, 1712–1730 (2018).

    Article  Google Scholar 

  14. Ronaldson-Bouchard, K. et al. Nature 556, 239–243 (2018).

    Article  CAS  Google Scholar 

  15. Zhu, W.-Z., Santana, L. F. & Laflamme, M. A. PLoS ONE 4, e5407 (2009).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada

    Wahiba Dhahri, Rocco Romagnuolo & Michael A. Laflamme

  2. McEwen Centre for Regenerative Medicine, University Health Network, Toronto, Ontario, Canada

    Wahiba Dhahri, Rocco Romagnuolo & Michael A. Laflamme

  3. Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada

    Michael A. Laflamme

  4. University of Toronto, Toronto, Ontario, Canada

    Michael A. Laflamme

Authors
  1. Wahiba Dhahri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rocco Romagnuolo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Michael A. Laflamme
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Michael A. Laflamme.

Ethics declarations

Competing interests

M.A.L. is a founding investigator, consultant and equity holder in BlueRock Therapeutics.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dhahri, W., Romagnuolo, R. & Laflamme, M.A. Training heart tissue to mature. Nat Biomed Eng 2, 351–352 (2018). https://doi.org/10.1038/s41551-018-0253-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41551-018-0253-7

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research