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A light-scattering method implemented by using fibre-optic technology that can be directly incorporated into standard vascular-access devices allows for real-time monitoring of blood coagulability in the operating room.
A scanning fibre endoscope, combining reflectance and laser-induced fluorescence emission of intrinsic fluorescent constituents in vascular tissue, provides real-time structural, biochemical and biological images of human atherosclerotic plaques.
A rapid, inexpensive and ultrasensitive assay that uses antibody-conjugated nanoparticle probes on the surface of a sensor chip quantifies tumour-derived extracellular vesicles to detect pancreatic cancer from 1 μl of blood plasma.
A man/machine interface based on the activity of spinal motor neurons reinnervating the muscles of a missing limb in amputees enables the generation of neural signals for potential prosthetic control.
By taking advantage of stimulated Raman spectroscopy and fibre-laser technology, virtual histology images can be obtained in real time in the operating room, with diagnostic quality comparable with that achieved via conventional histopathology.
A biocompatible, energy-harvesting electrochemical cell delivers power to a wireless sensor for an average of 6.1 days of temperature measurements in the gastrointestinal tract of pigs.
An artificial intelligence agent integrated with a cloud-based platform for multihospital collaboration performs equally as well as ophthalmologists in the diagnosis of congenital cataracts in a series of online tests and a multihospital clinical trial.
By targeting the surgical bed and circulating tumour cells, platelets conjugated with an antibody against an immune checkpoint protein prevent tumour recurrence and metastasis following resection of the primary tumour.
A hand-powered centrifuge made of two paper discs, string and wooden handles is shown to achieve rotational speeds of 125,000 r.p.m., separate pure plasma from whole blood in less than 1.5 minutes and isolate malaria parasites in 15 minutes.
A fluorescent nanoprobe that amplifies the fluorescent signal in a broad range of tumours allows for real-time tumour-acidosis-guided detection and surgery of occult, less-than-1-mm3 nodules in mice bearing head and neck or breast tumours.
A self-adjusting synthetic gene circuit in implanted mammalian cells senses insulin concentration and reverses the insulin-resistance syndrome in three mouse models by coordinating the expression of the insulin-sensitizing compound adiponectin.
Mediated by neovascularization, macrophages and giant cells drive the fibrotic encapsulation of implanted porous polymer scaffolds, as revealed by nonlinear intravital three-dimensional microscopy.
TGF-β-signalling inhibitors allow for the long-term expansion of epicardial cells derived from human pluripotent stem cells by means of the temporal modulation of canonical Wnt signalling under chemically defined xeno-free conditions.
Conjugation of exendin-4 — a drug to treat type 2 diabetes — with a poly(ethylene glycol) (PEG)-based brush polymer reduces the conjugate's reactivity towards anti-PEG antibodies and leads to lower blood glucose levels in mice for up to 5 days after a single injection.
Three methods for releasing solid stress in tumours provide two–dimensional mappings, sensitive estimates and in situ quantification of stress-induced tumour deformations — and thus stored elastic energy — via ultrasonography or optical microscopy.