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Isola, Ocañas et al. report age-related changes in the mouse ovarian transcriptome at single-cell resolution, demonstrating an increase in lymphocytes that corresponds to declines in collagen degradation and accumulation of multinucleated giant cells.
Griffin et al. present a versatile method for scalable and low-cost sequencing for the construction of epigenetic clocks. They assay 2,892 human or mouse samples, benchmark their method and assess diverse interventions.
Tijms et al. identify five molecular Alzheimer’s disease subtypes typified by hyperplasticity, impaired immune activation, RNA metabolism, and choroid plexus or blood–brain barrier function. Subtypes may need tailored cures.
Li and Guo et al. demonstrate that epigenetic dysregulation of the MLL complex at promoters of particular age-dependent genes results in their transcriptional downregulation and subsequent age-related dysfunction of neural stem and progenitor cells.
Yang et al. demonstrate that inhibition of early-acting autophagy genes in neurons extend C. elegans lifespan, improve neuronal proteostasis and increase exopher formation mediated by the autonomous WD40 domain-related function of ATG-16.2.