Volume 12 Issue 6, November 2019

This image shows histologic images of the colon of wildtype (top) and Cyba ^nmf333 (bottom) mice. The compromised dense mucus layer in Cyba ^nmf333 mice facilitates penetration of microbiota into crypts, leading to direct contact of bacteria with the epithelium. Cyba ^nmf333 mice have a missense mutation in Ncf1 (p22phox) which renders NADPH oxidases Nox1-3 inactive while preserving Nox4 activity. Image courtesy of Dr. Ulla Knaus and Dr. Dimitri Scholz, Conway Institute, School of Medicine, University College Dublin. For further information, please see the article in this issue, pages 1316–1326.