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Electron microscopy images of the colon of wild type (left), and Lypd8-/- (right) mice infected with C. rodentium. The images demonstrate increased numbers of A/E lesions and internalization of bacteria in the colonic epithelia of Lypd8-/- mice. Image courtesy of Ryu Okumura and Kiyoshi Takeda, Osaka University. For further information, please see the article in this issue, pages 75–85.