Volume 11 Issue 6, November 2018
Dunlap and colleagues describe a novel role for chemokine receptor CCR2 in the migration of alveolar macrophages out of the airways and into tuberculous granulomas during infection with M. tuberculosis. After airway adoptive transfer, alveolar macrophages expressing CCR2 (green) and Siglec F+ (Red) localized within tuberculosis granulomas in a CCR2 dependent manner, demonstrating a previously unknown mechanism of host defense against Mycobacterium tuberculosis. For further information see article in this issue, page 1727. Image Courtesy of Javier Rangel-Moreno, Micah D. Dunlap, and Shabaana A. Khader.
