TABLE OF CONTENTS
Volume 21, Issue 12 (December 2007)
Original Articles
Therapy
Aplidin synergizes with cytosine arabinoside: functional relevance of mitochondria in Aplidin-induced cytotoxicity
R Humeniuk, L G Menon, P J Mishra, G Saydam, G S A Longo-Sorbello, Y Elisseyeff, L D Lewis, M Aracil, J Jimeno, J R Bertino and D Banerjee
Leukemia 21: 2399-2405; advance online publication, August 23, 2007; doi:10.1038/sj.leu.2404911
Acute Leukemias
Serglycin proteoglycan in hematologic malignancies: a marker of acute myeloid leukemia
C U Niemann, L Kjeldsen, E Ralfkiaer, M K Jensen and N Borregaard
Leukemia 21: 2406-2410; advance online publication, October 11, 2007; doi:10.1038/sj.leu.2404975
Myelodysplasias
Monocytes are activated in patients with myelodysplastic syndromes and can contribute to bone marrow failure through CD40–CD40L interactions with T helper cells
S Meers, A Kasran, L Boon, J Lemmens, C Ravoet, M Boogaerts, G Verhoef, C Verfaillie and M Delforge
Leukemia 21: 2411-2419; advance online publication, September 6, 2007; doi:10.1038/sj.leu.2404940
Chronic Myeloproliferative Disorders
Marrow fibrosis and its relevance during imatinib treatment of chronic myeloid leukemia
G Buesche, A Ganser, B Schlegelberger, N von Neuhoff, D Gadzicki, H Hecker, O Bock, B Frye and H Kreipe
Leukemia 21: 2420-2427; advance online publication, September 6, 2007; doi:10.1038/sj.leu.2404917
The severity of FIP1L1–PDGFRA-positive chronic eosinophilic leukaemia is associated with polymorphic variation at the IL5RA locus
S Burgstaller, S Kreil, K Waghorn, G Metzgeroth, C Preudhomme, K Zoi, H White, D Cilloni, C Zoi, F Brito-Babapulle, C Walz, A Reiter and N C P Cross
Leukemia 21: 2428-2432; advance online publication, October 4, 2007; doi:10.1038/sj.leu.2404977
T cells from patients with polycythemia vera elaborate growth factors which contribute to endogenous erythroid and megakaryocyte colony formation
T Ishii, Y Zhao, J Shi, S Sozer, R Hoffman and M Xu
Leukemia 21: 2433-2441; advance online publication, August 16, 2007; doi:10.1038/sj.leu.2404899
Chronic Lymphocytic Leukemia
Comprehensive genetic characterization of CLL: a study on 506 cases analysed with chromosome banding analysis, interphase FISH, IgVH status and immunophenotyping
C Haferlach, F Dicker, S Schnittger, W Kern and T Haferlach
Leukemia 21: 2442-2451; advance online publication, September 6, 2007; doi:10.1038/sj.leu.2404935
Genetically identical twin transplantation for chronic lymphocytic leukemia
S Z Pavletic, G Zhou, K Sobocinski, G Marti, K Doney, J DiPersio, W Feremans, L Foroni, S Goodman, G Prentice, C LeMaistre, G Bandini, A Ferrant, N Jacobsen, I Khouri, R P Gale, A Wiestner, S Giralt, E Montserrat, W C Chan and C Bredeson for the Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, USA
Leukemia 21: 2452-2455; advance online publication, August 30, 2007; doi:10.1038/sj.leu.2404928
Short telomeres and high telomerase activity in T-cell prolymphocytic leukemia
A Röth, J Dürig, H Himmelreich, S Bug, R Siebert, U Dührsen, P M Lansdorp and G M Baerlocher
Leukemia 21: 2456-2462; advance online publication, September 27, 2007; doi:10.1038/sj.leu.2404968
Cytogenetics and Molecular Genetics
Further delineation of chromosomal consensus regions in primary mediastinal B-cell lymphomas: an analysis of 37 tumor samples using high-resolution genomic profiling (array-CGH)
S Wessendorf, T F E Barth, A Viardot, A Mueller, H A Kestler, H Kohlhammer, P Lichter, M Bentz, H Döhner, P Möller and C Schwaenen
Leukemia 21: 2463-2469; advance online publication, August 30, 2007; doi:10.1038/sj.leu.2404919
Cooperative transformation by MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins generated by the variant t(1;19) in acute lymphoblastic leukemia
V Prima and S P Hunger
Leukemia 21: 2470-2475; advance online publication, September 27, 2007; doi:10.1038/sj.leu.2404962
Oncogenes, Fusion Genes and Tumor Suppressor Genes
FLT3 regulates 
-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells
T Kajiguchi, E J Chung, S Lee, A Stine, H Kiyoi, T Naoe, M J Levis, L Neckers and J B Trepel
Leukemia 21: 2476-2484; advance online publication, September 13, 2007; doi:10.1038/sj.leu.2404923
Deregulation of the Wilms' tumour gene 1 protein (WT1) by BCR/ABL1 mediates resistance to imatinib in human leukaemia cells
E Svensson, K Vidovic, C Lassen, J Richter, T Olofsson, T Fioretos and U Gullberg
Leukemia 21: 2485-2494; advance online publication, August 30, 2007; doi:10.1038/sj.leu.2404924
Transcriptional Control and Deregulation and Signal Transduction and Cytokines
Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia
A Tonks, L Pearn, M Musson, A Gilkes, K I Mills, A K Burnett and R L Darley
Leukemia 21: 2495-2505; advance online publication, September 27, 2007; doi:10.1038/sj.leu.2404961
Lymphoma
Triggering of T-cell leukemia and dissemination of T-cell lymphoma in MMP-9-deficient mice
J-S Roy, C Van Themsche, M Demers, G Opdenakker, B Arnold and Y St-Pierre
Leukemia 21: 2506-2511; advance online publication, September 6, 2007; doi:10.1038/sj.leu.2404936
FOXP3+ regulatory T cells in cutaneous T-cell lymphomas: association with disease stage and survival
L M Gjerdrum, A Woetmann, N Odum, C M Burton, K Rossen, G L Skovgaard, L P Ryder and E Ralfkiaer
Leukemia 21: 2512-2518; advance online publication, August 23, 2007; doi:10.1038/sj.leu.2404913
Myeloma
Biological pathways and in vivo antitumor activity induced by Atiprimod in myeloma
P Neri, P Tassone, M Shammas, H Yasui, E Schipani, R B Batchu, S Blotta, R Prabhala, L Catley, M Hamasaki, T Hideshima, D Chauhan, G S Jacob, D Picker, S Venuta, K C Anderson and N C Munshi
Leukemia 21: 2519-2526; advance online publication, September 20, 2007; doi:10.1038/sj.leu.2404912
Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma
C S Chim, R Pang, T K Fung, C L Choi and R Liang
Leukemia 21: 2527-2536; advance online publication, September 20, 2007; doi:10.1038/sj.leu.2404939
Letters to the Editor
Male preponderance in chronic lymphocytic leukemia utilizing IGHV 1–69
R Walewska, A Majid, Z Davis, P Dusanjh, D B J Kennedy, D G Oscier and M J S Dyer
Leukemia 21: 2537-2538; advance online publication, June 28, 2007; doi:10.1038/sj.leu.2404836
Reply to 'Male preponderance in chronic lymphocytic leukemia utilizing IGHV1-69' When size of the sample matters
P Ghia, C Belessi, F Daví, R Rosenquist and K Stamatopoulos
Leukemia 21: 2539-2540; advance online publication, August 16, 2007; doi:10.1038/sj.leu.2404907
Treatment of AML and MDS relapsing after reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation
B Oran, S Giralt, D Couriel, C Hosing, E J Shpall, E de Meis, I F Khouri, M Qazilbash, P Anderlini, P Kebriaei, U Popat, A Carrasco-Yalan, R E Champlin and M de Lima
Leukemia 21: 2540-2544; advance online publication, July 5, 2007; doi:10.1038/sj.leu.2404828
Uncontrolled thrombocytosis in polycythemia vera is a risk for thrombosis, regardless of JAK2V617F mutational status
K Ohyashiki, D Akahane, A Gotoh, Y Ito, T Tauchi, K Miyazawa, Y Kimura and J H Ohyashiki
Leukemia 21: 2544-2545; advance online publication, July 5, 2007; doi:10.1038/sj.leu.2404829
Potential interaction of chemotherapy and gefitinib in the induction of hematologic neoplasia
M Ravindranathan, F J Klementich and D V Jones Jr
Leukemia 21: 2546-2547; advance online publication, July 26, 2007; doi:10.1038/sj.leu.2404851
MicroRNA losses in the frequently deleted region of 7q in SMZL
E Ruiz-Ballesteros, M Mollejo, M Mateo, P Algara, P Martínez and M A Piris
Leukemia 21: 2547-2549; advance online publication, July 12, 2007; doi:10.1038/sj.leu.2404853
Trisomy 3 is a specific genomic aberration of t(14;18) negative follicular lymphoma
H Tagawa, K Karube, Y Guo, M Takeshita, M Kikuchi, Y Morishima, S Nakamura, K Ohshima and M Seto
Leukemia 21: 2549-2551; advance online publication, July 5, 2007; doi:10.1038/sj.leu.2404817
Assessment of cellular origin and EBV status in a PTLD after double cord blood transplantation
G Reddiconto, P Chiusolo, A Fiorini, G Farina, L Laurenti, M Martini, S Marchetti, G Fadda, G Leone and S Sica
Leukemia 21: 2552-2554; advance online publication, June 28, 2007; doi:10.1038/sj.leu.2404818
Absolute lymphocyte count predicts therapeutic efficacy and survival at the time of radioimmunotherapy in patients with relapsed follicular lymphomas
L F Porrata, K Ristow, T E Witzig, N Tuinistra, T M Habermann, D J Inwards, S M Ansell, I N Micallef, P B Johnston and S N Markovic
Leukemia 21: 2554-2556; advance online publication, June 21, 2007; doi:10.1038/sj.leu.2404819
Modulation of cell apoptosis by AIR
M C Turco, A Lamberti, R Bisogni, M F Romano, A Petrella, M Ammirante, A Rosati, M d' Avenia, C Arra, E Spugnini and S Venuta
Leukemia 21: 2557-2559; advance online publication, July 19, 2007; doi:10.1038/sj.leu.2404837
Pleiotropic p27Kip1, BCR-ABL and leukemic stem cell: the trio in concert
A Sengupta and S Banerjee
Leukemia 21: 2559-2561; advance online publication, July 5, 2007; doi:10.1038/sj.leu.2404842
No evidence for amplification of V617F JAK2 in myeloproliferative disorders
A V Jones, D J Bunyan and N C P Cross
Leukemia 21: 2561-2563; advance online publication, July 5, 2007; doi:10.1038/sj.leu.2404845
Rituximab with chemotherapy improves survival of non-germinal center type untreated diffuse large B-cell lymphoma
B Saito, E Shiozawa, T Usui, H Nakashima, T Maeda, N Hattori, J Shimozuma, D Adachi, T Yamochi-Onizuka, M Takimoto, T Nakamaki, H Ota and S Tomoyasu
Leukemia 21: 2563-2566; advance online publication, June 28, 2007; doi:10.1038/sj.leu.2404844
Familial polycythemia vera with non-germ line JAK2V617F mutation sparing the abnormal and clonal granulopoiesis
K Hussein, O Bock, M Ballmaier, G Göhring, D Steinemann, U Lehmann, J Kemper, T Buhr and H Kreipe
Leukemia 21: 2566-2568; advance online publication, July 12, 2007; doi:10.1038/sj.leu.2404846
The CALM–AF10 fusion is a rare event in acute megakaryoblastic leukemia
O Greiner, B C Bornhauser, E Delabesse, P Ballerini, J Landman-Parker and J P Bourquin
Leukemia 21: 2568-2569; advance online publication, July 5, 2007; doi:10.1038/sj.leu.2404835
Characterization of graft-versus-leukemia responses in patients treated for advanced chronic lymphocytic leukemia with donor lymphocyte infusions after in vitro T-cell depleted allogeneic stem cell transplantation following reduced-intensity conditioning
M Hoogendoorn, I Jedema, R M Y Barge, S A P van Luxemburg-Heijs, F Beaumont, E W A Marijt, R Willemze and J H F Falkenburg
Leukemia 21: 2569-2574; advance online publication, July 5, 2007; doi:10.1038/sj.leu.2404838
Obituary
Giuseppe Bigi (1944–2002)
N Sacchi
Leukemia 21: 2575; doi:10.1038/sj.leu.2404950
Corrigenda
JAK2-V617F activating mutation in acute myeloid leukemia: prognostic impact and association with other molecular markers FREE
C Vicente, I Vázquez, N Marcotegui, A Conchillo, C Carranza, G Rivell, E Bandrés, I Cristobal, I Lahortiga, M J Calasanz and M D Odero
Leukemia 21: 2576; doi:10.1038/sj.leu.2405004
