TABLE OF CONTENTS

Volume 17, Issue 1 (January 2003)

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Leading Article

Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia FREE

J-M Luo, H Yoshida, S Komura, N Ohishi, L Pan, K Shigeno, I Hanamura, K Miura, S Iida, R Ueda, T Naoe, Y Akao, R Ohno and K Ohnishi

Leukemia 17: 1-8; doi:10.1038/sj.leu.2402725

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Reviews

New mechanisms of AML1 gene alteration in hematological malignancies FREE

C Roumier, P Fenaux, M Lafage, M Imbert, V Eclache and C Preudhomme

Leukemia 17: 9-16; doi:10.1038/sj.leu.2402766

Molecular determinants of glucocorticoid sensitivity and resistance in acute lymphoblastic leukemia FREE

W J E Tissing, J P P Meijerink, M L den Boer and R Pieters

Leukemia 17: 17-25; doi:10.1038/sj.leu.2402733

Molecular and cellular aspects of HTLV-1 associated leukemogenesis in vivo  FREE

F Mortreux, A-S Gabet and E Wattel

Leukemia 17: 26-38; doi:10.1038/sj.leu.2402777

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Commentary

High numbers of mobilized stem cells in patients with acute myeloid leukemia in first complete remission: good or bad? FREE

T de Witte

Leukemia 17: 39-40; doi:10.1038/sj.leu.2402796

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Original Manuscripts

Immunomodulatory analogs of thalidomide inhibit growth of Hs Sultan cells and angiogenesis in vivo  FREE

S Lentzsch, R LeBlanc, K Podar, F Davies, B Lin, T Hideshima, L Catley, D I Stirling and K C Anderson

Leukemia 17: 41-44; doi:10.1038/sj.leu.2402745

Long-term outcome with pentostatin treatment in hairy cell leukemia patients. A French retrospective study of 238 patients FREE

F Maloisel, L Benboubker, M Gardembas, B Coiffier, M Divine, C Sebban, M Blanc, J-F Abgrall, P Lederlin, J-L Harousseau, A-M Blaise, B Grosbois, P Morice, C Ghandour and S Castaigne

Leukemia 17: 45-51; doi:10.1038/sj.leu.2402784

Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4 FREE

M Broggini, S V Marchini, E Galliera, P Borsotti, G Taraboletti, E Erba, M Sironi, J Jimeno, G T Faircloth, R Giavazzi and M d'Incalci

Leukemia 17: 52-59; doi:10.1038/sj.leu.2402788

The stem cell mobilizing capacity of patients with acute myeloid leukemia in complete remission correlates with relapse risk: results of the EORTC-GIMEMA AML-10 trial FREE

S Keating, S Suciu, T de Witte, R Zittoun, F Mandelli, A Belhabri, S Amadori, W Fibbe, E Gallo, G Fillet, B Varet, G Meloni, A Hagemeijer, P Fazi, G Solbu and R Willemze on behalf of the EORTC and GIMEMA Leukemia Groups

Leukemia 17: 60-67; doi:10.1038/sj.leu.2402782

High percentage of CD34-positive cells in autologous AML peripheral blood stem cell products reflects inadequate in vivo purging and low chemotherapeutic toxicity in a subgroup of patients with poor clinical outcome FREE

N Feller, G J Schuurhuis, M A van der Pol, G Westra, G W D Weijers, A van Stijn, P C Huijgens and G J Ossenkoppele

Leukemia 17: 68-75; doi:10.1038/sj.leu.2402781

Acute myeloid leukemia with MLL rearrangements: clinicobiological features, prognostic impact and value of flow cytometry in the detection of residual leukemic cells FREE

L Muñoz, J F Nomdedéu, N Villamor, R Guardia, D Colomer, J M Ribera, J P Torres, J J Berlanga, C Fernández, A Llorente, M P Queipo de Llano, J M Sánchez, S Brunet and J Sierra for the Spanish CETLAM Group

Leukemia 17: 76-82; doi:10.1038/sj.leu.2402708

Methylation of the hMLH1 promoter and its association with microsatellite instability in acute myeloid leukemia FREE

C H Seedhouse, E P Das-Gupta and N H Russell

Leukemia 17: 83-88; doi:10.1038/sj.leu.2402747

Clinicopathologic correlations of bone marrow angiogenesis in chronic myeloid leukemia: a morphometric study FREE

P Korkolopoulou, N Viniou, N Kavantzas, E Patsouris, I Thymara, P M Pavlopoulos, E Terpos, K Stamatopoulos, E Plata, K Anargyrou, A Androulaki, P Davaris and X Yataganas

Leukemia 17: 89-97; doi:10.1038/sj.leu.2402769

C-fms expression correlates with monocytic differentiation in PML-RARalpha+ acute promyelocytic leukemia FREE

R Riccioni, E Saulle, S Militi, N M Sposi, M Gualtiero, N Mauro, M Mancini, D Diverio, F Lo Coco, C Peschle and U Testa

Leukemia 17: 98-113; doi:10.1038/sj.leu.2402812

Better detection of FLT3 internal tandem duplication using peripheral blood plasma DNA FREE

I Jilani, E Estey, T Manshuri, M Caligiuri, M Keating, F Giles, D Thomas, H Kantarjian and M Albitar

Leukemia 17: 114-119; doi:10.1038/sj.leu.2402743

FLT3 mutations in acute myeloid leukemia cell lines FREE

H Quentmeier, J Reinhardt, M Zaborski and H G Drexler

Leukemia 17: 120-124; doi:10.1038/sj.leu.2402740

Diagnostic role and prognostic significance of a simplified immunophenotypic classification of mature B cell chronic lymphoid leukemias FREE

L Cro, A Guffanti, M Colombi, B Cesana, M G Grimoldi, C Patriarca, M Goldaniga, A Neri, D Intini, A Cortelezzi, A T Maiolo and L Baldini

Leukemia 17: 125-132; doi:10.1038/sj.leu.2402737

Predictive value of serum thymidine kinase level for Ig-V mutational status in B-CLL FREE

C Magnac, R Porcher, F Davi, J Nataf, B Payelle-Brogard, R P Tang, P Oppezzo, V Lévy, G Dighiero and F Ajchenbaum-Cymbalista

Leukemia 17: 133-137; doi:10.1038/sj.leu.2402780

Flow cytometric follow-up of minimal residual disease in bone marrow gives prognostic information in children with acute lymphoblastic leukemia FREE

E Björklund, J Mazur, S Söderhäll and A Porwit-MacDonald

Leukemia 17: 138-148; doi:10.1038/sj.leu.2402736

Long-term study of the clinical significance of loss of heterozygosity in childhood acute lymphoblastic leukemia FREE

S Takeuchi, K Tsukasaki, C R Bartram, T Seriu, M Zimmermann, M Schrappe, N Takeuchi, S Park, H Taguchi and H P Koeffler

Leukemia 17: 149-154; doi:10.1038/sj.leu.2402727

Diphtheria toxin-interleukin-3 fusion protein (DT388IL3) prolongs disease-free survival of leukemic immunocompromised mice FREE

J H Black, J A McCubrey, M C Willingham, J Ramage, D E Hogge and A E Frankel

Leukemia 17: 155-159; doi:10.1038/sj.leu.2402744

Primary murine MSC show highly efficient homing to the bone marrow but lose homing ability following culture FREE

W J C Rombouts and R E Ploemacher

Leukemia 17: 160-170; doi:10.1038/sj.leu.2402763

CD38 expression by hematopoietic stem cells of newborn and juvenile mice FREE

Y Higuchi, H Zeng and M Ogawa

Leukemia 17: 171-174; doi:10.1038/sj.leu.2402785

Proteoglycans on bone marrow endothelial cells bind and present SDF-1 towards hematopoietic progenitor cells FREE

T Netelenbos, J van den Born, F L Kessler, S Zweegman, P A Merle, J W van Oostveen, J J Zwaginga, P C Huijgens and A M Dräger

Leukemia 17: 175-184; doi:10.1038/sj.leu.2402738

Qualitative and quantitative analysis of human herpesviruses in chronic and acute B cell lymphocytic leukemia and in multiple myeloma FREE

S Hermouet, C A Sutton, T M Rose, R J Greenblatt, I Corre, R Garand, A M Neves, R Bataille and J W Casey

Leukemia 17: 185-195; doi:10.1038/sj.leu.2402748

Clinical significance of nm23-H1 proteins expressed on cell surface in non-Hodgkin's lymphoma FREE

N Niitsu, Y Honma, K Iijima, T Takagi, M Higashihara, U Sawada and J Okabe-Kado

Leukemia 17: 196-202; doi:10.1038/sj.leu.2402699

Expression and function of chemokine receptors in human multiple myeloma FREE

C Möller, T Strömberg, M Juremalm, K Nilsson and G Nilsson

Leukemia 17: 203-210; doi:10.1038/sj.leu.2402717

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Molecular Targets for Therapy (MTT)

Chemosensitization of myeloma plasma cells by an antisense-mediated downregulation of Bcl-2 protein FREE

N W C J van de Donk, M M J Kamphuis, M van Dijk, H P E Borst, A C Bloem and H M Lokhorst

Leukemia 17: 211-219; doi:10.1038/sj.leu.2402768

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Debate Round Table

Editorial: Chimerism testing after allogeneic stem cell transplantation: importance of timing and optimal technique for testing in different clinical–biological situations FREE

Nicole Muller-Bérat, MD, PhD and Prof Thomas Lion, MD, PhD

Leukemia 17: 220; doi:10.1038/sj.leu.2402754

Interference of dye-associated fluorescence signals with quantitative analysis of chimerism by capillary electrophoresis FREE

E Schraml and T Lion

Leukemia 17: 221-223; doi:10.1038/sj.leu.2402755

Quantitative analysis of chimerism after allogeneic stem cell transplantation by PCR amplification of microsatellite markers and capillary electrophoresis with fluorescence detection: the Vienna experience FREE

E Schraml, H Daxberger, F Watzinger and T Lion

Leukemia 17: 224-227; doi:10.1038/sj.leu.2402756

Quantitative analysis of chimerism after allogeneic stem cell transplantation by PCR amplification of microsatellite markers and capillary electrophoresis with fluorescence detection: the Geneva experience FREE

Y Chalandon, S Vischer, C Helg, B Chapuis and E Roosnek

Leukemia 17: 228-231; doi:10.1038/sj.leu.2402758

Quantitative analysis of chimerism after allogeneic stem cell transplantation by PCR amplification of microsatellite markers and capillary electrophoresis with fluorescence detection: the Frankfurt experience FREE

U Koehl, O Beck, R Esser, E Seifried, T Klingebiel, D Schwabe and C Seidl

Leukemia 17: 232-236; doi:10.1038/sj.leu.2402760

Quantitative analysis of chimerism after allogeneic stem cell transplantation by PCR amplification of microsatellite markers and capillary electrophoresis with fluorescence detection: the Tuebingen experience FREE

H Kreyenberg, W Hölle, S Möhrle, D Niethammer and P Bader

Leukemia 17: 237-240; doi:10.1038/sj.leu.2402761

Quantitative analysis of chimerism after allogeneic stem cell transplantation by PCR amplification of microsatellite markers and capillary electrophoresis with fluorescence detection: the Paris–Robert Debré experience FREE

C Acquaviva, M Duval, D Mirebeau, R Bertin and H Cavé

Leukemia 17: 241-246; doi:10.1038/sj.leu.2402762

Quantitative analysis of chimerism after allogeneic bone marrow transplantation using immunomagnetic selection and fluorescent microsatellite PCR FREE

J P Hancock, N J Goulden, A Oakhill and C G Steward

Leukemia 17: 247-251; doi:10.1038/sj.leu.2402759

Summary: Reports on quantitative analysis of chimerism after allogeneic stem cell transplantation by PCR amplification of microsatellite markers and capillary electrophoresis with fluorescence detection FREE

T Lion on behalf of the participants of the current round of the Debate

Leukemia 17: 252-254; doi:10.1038/sj.leu.2402753

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Bio-Technical Methods Section (BTS)

Is t(14;18)(q32;q21) a constant finding in follicular lymphoma? An interphase FISH study on 63 patients FREE

A Godon, A Moreau, P Talmant, L Baranger-Papot, F Geneviève, N Milpied, M Zandecki and H Avet-Loiseau

Leukemia 17: 255-259; doi:10.1038/sj.leu.2402739

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Tools

IMGT® databases, web resources and tools for immunoglobulin and T cell receptor sequence analysis, http://imgt.cines.fr FREE

M-P Lefranc

Leukemia 17: 260-266; doi:10.1038/sj.leu.2402637

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Correspondence

Ubiquinone does not rescue acute myeloid leukemia cells from growth inhibition by statins FREE

L P Burke, L D Lewis and R P Perez

Leukemia 17: 267-268; doi:10.1038/sj.leu.2402695

Inhibition affecting RQ-PCR-based assessment of minimal residual disease in acute lymphoblastic leukemia: reversal by addition of bovine serum albumin FREE

J Moppett, V H J van der Velden, A J M Wijkhuijs, J Hancock, J J M van Dongen and N Goulden

Leukemia 17: 268-270; doi:10.1038/sj.leu.2402751

Clinical activity of arsenic trioxide in Burkitt-like lymphoma FREE

F Ravandi and K van Besien

Leukemia 17: 271-272; doi:10.1038/sj.leu.2402735

Zinc modulates c-Myc/Mad1 balance in human leukemia cells FREE

M I Sirinian, S Pisegna, M Paroli, S Militi, U Testa and C Peschle

Leukemia 17: 272-274; doi:10.1038/sj.leu.2402746

Mutation of BRAF is uncommon in AML FAB type M1 and M2 FREE

M L Smith, J Snaddon, M Neat, M Cambal-Parrales, R Arch, T A Lister and J Fitzgibbon

Leukemia 17: 274-275; doi:10.1038/sj.leu.2402787

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