Web Focus
Resistant Hypertension
Resistant or difficult-to-treat hypertension is an increasingly common clinical problem. Such patients are at increased cardiovascular risk compared to patients with more easily controlled hypertension. Causes of resistant hypertension are multifactorial, but recent studies suggest that inappropriate fluid retention and heightened sympathetic tone likely play key roles. This web focus highlights recent advances in our understanding of mechanisms and complications of resistant hypertension as well as emerging therapies for this particular disorder.
Review
Medication adherence and resistant hypertension
D J Hyman and V Pavlik
Journal of Human Hypertension 29: 213-218; Published online, 11 September 2014; doi:10.1038/jhh.2014.73
Original Articles
Blood pressure response to renal nerve stimulation in patients undergoing renal denervation: a feasibility study
P Gal, M R de Jong, J J J Smit, A Adiyaman, J A Staessen and A Elvan
Journal of Human Hypertension 29: 292-295; Published online, 23 October 2014; doi:10.1038/jhh.2014.91
Medication adherence and resistant hypertension
D J Hyman and V Pavlik
Journal of Human Hypertension 29: 213-218; Published online, 11 September 2014; doi:10.1038/jhh.2014.73
Effect of spironolactone on diastolic function in hypertensive left ventricular hypertrophy
A Gupta, C G Schiros, K K Gaddam, I Aban, T S Denney, S G Lloyd, S Oparil, L J Dell'Italia, D A Calhoun and H Gupta
Journal of Human Hypertension 29: 241-246; Published online, 18 September 2014; doi:10.1038/jhh.2014.83
Effect of aldosterone antagonists on blood pressure in patients with resistant hypertension: a meta-analysis
G Liu, X-X Zheng, Y-L Xu, J Lu, R-T Hui and X-H Huang
Journal of Human Hypertension 29: 159-166; Published online, 31 July 2014; doi:10.1038/jhh.2014.64
Low-dose spironolactone reduces plasma fibulin-1 levels in patients with type 2 diabetes and resistant hypertension
C S Oxlund, C Cangemi, J E Henriksen, I A Jacobsen, J Gram, K Schousboe, L Tarnow, W S Argraves and L M Rasmussen
Journal of Human Hypertension 29: 28-32; Published online, 17 April 2014; doi:10.1038/jhh.2014.27
Patients with resistant hypertension have more peripheral arterial disease than other uncontrolled hypertensives
P E Korhonen, H Kautiainen and I Kantola
Journal of Human Hypertension 29: 46-49; Published online, 31 July 2014; doi:10.1038/jhh.2014.65
Importance of thorough investigation of resistant hypertension before renal denervation: should compliance to treatment be evaluated systematically?
J Rosa, T Zelinka, O Petrák, B Štrauch, Z Šomlóová, T Indra, R Holaj, K Čurila, P Toušek, M Šenitko, P Widimský and J Widimský Jr
Journal of Human Hypertension 28: 684-688; Published online, 06 February 2014; doi:10.1038/jhh.2014.3
Drug-resistant hypertensive patients responding to multielectrode renal denervation exhibit improved heart rate dynamics and reduced arrhythmia burden
C Tsioufis, V Papademetriou, D Tsiachris, K Dimitriadis, A Kasiakogias, A Kordalis, V Antonakis, A Kefala, C Thomopoulos, I Kallikazaros, E O-Y Lau and C Stefanadis
Journal of Human Hypertension 28: 587-593; Published online, 13 March 2014; doi:10.1038/jhh.2014.14
Apparent and true resistant hypertension: definition, prevalence and outcomes
E Judd and D A Calhoun
Journal of Human Hypertension 28: 463-468; Published online, 16 January 2014; doi:10.1038/jhh.2013.140
Heart rate and heart rate variability in resistant versus controlled hypertension and in true versus white-coat resistance
A de la Sierra, D A Calhoun, E Vinyoles, J R Banegas, J J de la Cruz, M Gorostidi, J Segura and L M Ruilope
Journal of Human Hypertension 28: 416-420; Published online, 09 January 2014; doi:10.1038/jhh.2013.135
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