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New devices for TAVI: technologies and initial clinical experiences

Maurizio Taramasso, Alberto Pozzoli, Azeem Latib, Giovanni La Canna, Antonio Colombo, Francesco Maisano & Ottavio Alfieri

Transcatheter aortic valve implantation (TAVI) is increasingly used to treat patients with aortic stenosis for whom the risks associated with surgery are very high. In this Review, the new generation of TAVI devices are discussed, many of which have features that allow repositioning of the device and reduce paravalvular leakage.

Current Issue

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OPINION: A TACTful reappraisal of chelation therapy in cardiovascular disease

Mandeep S. Sidhu, Basil M. Saour & William E. Boden

Chelation therapy with ethylenediamine tetra acetic acid is increasingly being used in patients with cardiovascular disease, without definitive evidence for its efficacy. In this Perspectives article, Sidhu et al. discuss data from major studies of chelation therapy in this field, with particular emphasis on TACT. They opine that the findings from this trial are not robust and do not marshal evidence in support of the potential clinical use of chelation therapy for cardiovascular disease.

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News and Views: Acute coronary syndromes: Targeting inflammation—what has the VISTA-16 trial taught us?

Michelle L. O'Donoghue

Review: Inherited risk factors for venous thromboembolism

Ida Martinelli, Valerio De Stefano & Pier Mannuccio Mannucci

Review: Treatment of dystrophin cardiomyopathies

Josef Finsterer & Linda Cripe