Short Communication

International Journal of Obesity (2011) 35, 744–747; doi:10.1038/ijo.2010.188; published online 7 September 2010

Inverse associations between long-term weight change and serum concentrations of persistent organic pollutants

J S Lim1,2, H-K Son1,3, S-K Park1, D R Jacobs Jr4,5 and D-H Lee1

  1. 1Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
  2. 2Department of Preventive Medicine, School of Medicine, Eulji University, Daejeon, Korea
  3. 3Department of Occupational and Environmental Medicine, CHA Gumi Medical Center, CHA University, Kyungsangbuk-do, Korea
  4. 4Department of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN, USA
  5. 5Department of Nutrition, University of Oslo, Oslo, Norway

Correspondence: Dr D-H Lee, Department of Preventive Medicine, School of Medicine, Kyungpook National University, 101 Dongin-dong, Jung-gu, Daegu 700-422, Korea. E-mail: lee_dh@knu.ac.kr

Received 14 May 2010; Revised 29 June 2010; Accepted 18 July 2010; Published online 7 September 2010.

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Abstract

There is emerging evidence that persistent organic pollutants (POPs) can increase the risk of various chronic diseases. As POPs mainly bioaccumulate in adipose tissue, weight change can affect serum concentrations of POPs. However, there are few population-based studies on effects of long-term weight change on serum concentrations of POPs. We examined associations between self-reported weight change over 1 year and 10 years and serum concentrations of seven POPs in 1099 adults aged greater than or equal to40. Serum concentrations of most POPs were higher in those with long-term weight loss, whereas they were lower in those with long-term weight gain. Adjusted correlation coefficients of each POP with weight change for 10 years were −0.23 (P<0.01) for trans-nonachlor, −0.16 (P<0.01) for p,p′-dichlorodiphenyldichloroethylene, and −0.21 (P<0.01) for β-hexachlorocyclohexane, −0.16 (P<0.01) for PCB169, −0.20 (P<0.01) for PCB180 and −0.17 (P<0.01) for 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin. Weight change for 1 year showed similar but weaker associations, compared with those of long-term weight changes. Although both beneficial health effects after weight loss and harmful health effects after weight gain are generally expected, changes in serum concentrations of POPs in relation to weight change may act on health in directions opposite to what we expect with weight change.

Keywords:

adipose tissue; persistent organic pollutants (POPs); weight gain; weight loss

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