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Pistachio diet improves erectile function parameters and serum lipid profiles in patients with erectile dysfunction

Abstract

We investigated the effects of Antep pistachio on International Index of Erectile Function (IIEF) scores, penile color Doppler ultrasound (PCDU) parameters and serum lipid levels in patients with ED. A total of 17 married male patients with ED for at least 12 months were included in this prospective study. Patients were put on a 100 g pistachio nuts diet for 3 weeks. IIEF and PCDU were evaluated before and after the pistachio diet. In addition, plasma total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglyceride were measured before and after dietary modifications from all subjects. Mean IIEF-15 score was 36±7.5 before the diet and 54.2±4.9 after the diet (P=0.001). Similarly, an increase in all five domains of IIEF was observed after the diet (P<0.05). Mean peak systolic velocity values before and after the pistachio diet were 35.5±15.2 and 43.3±12.4 cm s–1, respectively (P=0.018). After the pistachio diet, TC and LDL levels decreased significantly, whereas HDL level increased (P=0.008, 0.007 and 0.001, respectively). We demonstrated that a pistachio diet improved IIEF scores and PCDU parameters without any associated side effects in patients with ED. Furthermore, the lipid parameters showed statistically significant improvements after this diet.

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References

  1. Simonsen U, Garcia-Sacristan A, Prieto D . Penile arteries and erection. J Vasc Res 2002; 39: 283–303.

    Article  CAS  Google Scholar 

  2. Martin-Morales A, Sanchez-Cruz JJ, Saenz de Tejeda I, Rodriguez-Vela L, Jimenez-Cruz JF, Burgos-Rodriguez R . Prevalence and independent risk factors for erectile dysfunction in Spain: results of the Epidemiologia de la Disfunction Erectil Masculina Study. J Urol 2001; 166: 569–574.

    Article  CAS  Google Scholar 

  3. Michal V . Arterial disease as a cause of impotence. Clin Endocrinol Metab 1982; 11: 725–748.

    Article  CAS  Google Scholar 

  4. Gentile C, Tesoriere L, Butera D, Fazzari M, Monastero M, Allegra M et al. Antioxidant activity of Sicilian pistachio (Pistacia vera L. var. Bronte) nut extract and its bioactive components. J Agric Food Chem 2007; 55: 643–648.

    Article  CAS  Google Scholar 

  5. Nyquist RC . Nuts nutrition and health benefits of daily use. Nutr Today 1997; 32: 157–163.

    Article  Google Scholar 

  6. Sari I, Baltaci Y, Bagci C, Davutoglu V, Erel O, Celik H et al. Effect of pistachio diet on lipid parameters, endothelial function, inflammation, and oxidative status: a prospective study. Nutrition 2010; 26: 399–404.

    Article  CAS  Google Scholar 

  7. Kloner RA . Erectile dysfunction and cardiovascular risk factors. Urol Clin North Am 2005; 32: 397–402.

    Article  Google Scholar 

  8. Araujo AB, Hall SA, Ganz P, Chiu GR, Rosen RC, Kupelian V et al. Does erectile dysfunction contribute to cardiovascular disease risk prediction beyond the Framingham risk score? J Am Coll Cardiol 2010; 55: 350–356.

    Article  CAS  Google Scholar 

  9. Kris-Etherton PM, Zhao G, Binkoski AE, Coval SM, Etherton TD . The effects of nuts on coronary heart disease risk. Nutr Rev 2001; 59: 103–111.

    Article  CAS  Google Scholar 

  10. Dreher ML, Maher CV, Kearney P . The traditional and emerging role of nuts in healthful diets. Nutr Rev 1996; 54: 241–245.

    Article  CAS  Google Scholar 

  11. Sheridan MJ, Cooper JN, Erario M, Cheifetz CE . Pistachio nut consumption and serum lipid levels. J Am Coll Nutr 2007; 26: 141–148.

    Article  CAS  Google Scholar 

  12. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A . The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997; 49: 822–830.

    Article  CAS  Google Scholar 

  13. Rosen RC, Cappelleri JC, Smith MD, Lipsky J, Peña BM . Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res 1999; 11: 319–326.

    Article  CAS  Google Scholar 

  14. Kocyigit A, Koylu AA, Keles H . Effects of pistachio nuts consumption on plasma lipid profile and oxidative status in healthy volunteers. Nutr Metab Cardiovasc Dis 2006; 16: 202–209.

    Article  CAS  Google Scholar 

  15. Edwards K, Kwaw I, Matud J, Kurtz I . Effect of pistachio nuts on serum lipid levels in patients with moderate hypercholesterolemia. J Am Coll Nutr 1999; 18: 229–232.

    Article  CAS  Google Scholar 

  16. Wilkins CJ, Sriprasad S, Sidhu PS . Colour doppler ultrasound of the penis. Clin Radiol 2003; 58: 514–523.

    Article  CAS  Google Scholar 

  17. Kurowski EM, Carroll KK . Hypercholesterolemic responses in rabbits to selected groups of dietary essential amino acids. J Nutr 1994; 124: 364–370.

    Article  Google Scholar 

  18. Slater TF . Free-radical mechanisms in tissue injury. Biochem J 1984; 222: 1–15.

    Article  CAS  Google Scholar 

  19. Tokusoglu O, Unal MK, Yemis F . Determination of the phytoalexin resveratrol (3,5,4′-trihydroxystilbene) in peanuts and pistachios by high-performance liquid chromatographic diode array (HPLC-DAD) and gas chromatography-mass spectrometry (GC-MS). J Agric Food Chem 2005; 53: 5003–5009.

    Article  CAS  Google Scholar 

  20. Pasqualini L, Cortese C, Marchesi S, Siepi D, Pirro M, Vaudo G et al. Paraoxonase-1 activity modulates endothelial function in patients with peripheral arterial disease. Atherosclerosis 2005; 183: 349–354.

    Article  CAS  Google Scholar 

  21. Ciftci H, Yeni E, Savas M, Verit A, Celik H . Paraoxonase activity in patients with erectile dysfunction. Int J Impot Res 2007; 19: 517–520.

    Article  CAS  Google Scholar 

  22. Aksoy N, Aksoy M, Bagci C, Gergerlioglu HS, Celik H, Herken E et al. Pistachio intake increase high density lipoprotein levels and inhibits low-density lipoprotein oxidation in rats. Tohoku J Exp Med 2007; 212: 43–48.

    Article  CAS  Google Scholar 

  23. Sullivan ME, Keoghane SR, Miller MA . Vascular risk factors and erectile dysfunction. BJU Int 2001; 87: 838–845.

    Article  CAS  Google Scholar 

  24. Tanner FC, Noll G, Boulanger CM, Luscher TF . Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxide. Circulation 1991; 83: 2012–2020.

    Article  CAS  Google Scholar 

  25. Rosenfeld ME . Oxidized LDL affects multiple atherogenic cellular responses. Circulation 1991; 83: 2137–2140.

    Article  CAS  Google Scholar 

  26. Kugiyama K, Kerns SA, Morrisett JD, Roberts R, Henry PD . Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins. Nature 1990; 344: 160–162.

    Article  CAS  Google Scholar 

  27. Leung WH, Lau CP, Wong CK . Beneficial effect of cholesterol-lowering therapy on coronary endothelium dependent relaxation in hypercholesterolaemic patients. Lancet 1993; 341: 1496–1500.

    Article  CAS  Google Scholar 

  28. Azadzoi K, Saenz de Tejada I . Hypercholesterolemia impairs endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle. J Urol 1991; 146: 238–240.

    Article  CAS  Google Scholar 

  29. Wei M, Macera CA, Davis DR, Hornung CA, Nankin HR, Blair SN . Total cholesterol and high density lipoprotein cholesterol as important predictors of erectile dysfunction. Am J Epidemiol 1994; 140: 930–937.

    Article  CAS  Google Scholar 

  30. Pinnock CB, Stapleton AM, Marshall VR . Erectile dysfunction in the community: a prevalence study. Med J Aust 1999; 171: 353–357.

    Article  CAS  Google Scholar 

  31. Manning M, Schmidt P, Juenemann KP, Alken P . The role of blood lipids in erectile failure. Int J Impot Res 1996; 8: 167.

    Google Scholar 

  32. Nikoobakht M, Pourkasmaee M, Nasseh H . The relationship between lipid profile and erectile dysfunction. Urol J 2005; 2: 40–44.

    PubMed  Google Scholar 

  33. Roumeguere TH, Wespes E, Carpentier Y, Hoffmann P, Schulman CC . Erectile dysfunction is associated with a high prevalence of hyperlipidemia and coronary heart disease risk. Eur Urol 2003; 44: 355–359.

    Article  Google Scholar 

  34. Jones PJ, MacDougall DE, Ntanios F, Vanstone CA . Dietary phytosterols as cholesterol-lowering agents in humans. Can J Physiol Pharmacol 1997; 75: 217–227.

    Article  CAS  Google Scholar 

  35. Vajifdar BU, Goyal VS, Lokhandwala YY, Mhamunkar SR, Mahadik SP, Gawad AK et al. Is dietary fiber beneficial in chronic ischemic heart disease? J Assoc Physicians India 2000; 48: 871–876.

    CAS  PubMed  Google Scholar 

  36. Kurowska EM, Carroll KK . Hypercholesterolemic responses in rabbits to selected groups of dietary essential amino acids. J Nutr 1994; 124: 364–370.

    Article  CAS  Google Scholar 

  37. Awada AB, Hartatia MS, Finka CS . Phytosterol feeding induces alteration in testosterone metabolism in rat tissues. J Nutr Biochem 1998; 9: 712–717.

    Article  Google Scholar 

  38. Jeremy JY, Angelini GD, Khan M, Mikhailidis DP, Morgan RJ, Thompson CS et al. Platelets, oxidant stress and erectile dysfunction: an hypothesis. Cardiovasc Res 2000; 46: 50–54.

    Article  CAS  Google Scholar 

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Aldemir, M., Okulu, E., Neşelioğlu, S. et al. Pistachio diet improves erectile function parameters and serum lipid profiles in patients with erectile dysfunction. Int J Impot Res 23, 32–38 (2011). https://doi.org/10.1038/ijir.2010.33

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