Ezzelarab et al. report that regulatory dendritic cells administered prior to transplantation modulate alloimmunity and increase kidney allograft survival. This finding provides the first evidence of the immunosuppressive efficacy of modified dendritic cells in a stringent pre-clinical primate model, offering hope that long-term immunosuppression of transplant recipients could be minimized or avoided.
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References
Ezzelerab M. B. et al. Regulatory dendritic cell infusion prolongs kidney allograft survival in nonhuman primates. Am. J. Transplant. 13, 1989–2005 (2013).
Steinman R. M. & Banchereau, J. Taking dendritic cells into medicine. Nature 449, 419–426 (2007).
Tacken, P. J., de Vries, I. J., Torensma, R. & Figdor, C. G. Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting. Nat. Rev. Immunol. 7, 790–802 (2007).
Mahnke, K., Schmitt, E., Bonifaz, L., Enk, A. H. & Jonuleit, H. Immature, but not inactive: the tolerogenic function of immature dendritic cells. Immunol. Cell Biol. 80, 477–483 (2002).
Coates, P. T., Colvin, B. L., Hackstein, H. & Thomson, A. W. Manipulation of dendritic cells as an approach to improved outcomes in transplantation. Expert Rev. Mol. Med. 4, 1–21 (2002).
Zahorchak, A. F. et al. Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques. Transplantation 84, 196–206 (2007).
Wojciechowski, D. & Vincenti, F. Belatacept for prevention of acute rejection in adult patients who have had a kidney transplant: an update. Biologics 6, 385–393 (2012).
Morelli, A. E. & Thomson, A. W. Tolerogenic dendritic cells and the quest for transplant tolerance. Nat. Rev. Immunol. 7, 610–621 (2007).
Levitsky, J. et al. Inhibitory effects of belatacept on allospecific regulatory T-cell generation in humans. Transplantation http://dx.doi.org/10.1097/TP.0b013e31829f1607.
Lo, D. J. et al. Belatacept and sirolimus prolong nonhuman primate renal allograft survival without a requirement for memory T cell depletion. Am. J. Transplant. 13, 320–328 (2013).
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Azimzadeh, A., Bromberg, J. Negative vaccination to modulate transplant immunity. Nat Rev Nephrol 9, 557–559 (2013). https://doi.org/10.1038/nrneph.2013.172
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DOI: https://doi.org/10.1038/nrneph.2013.172
