A recent report provides a rare example of a potential new class of antibiotics. Dan Jones investigates the difficulties of finding such drugs.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
The challenge of intracellular antibiotic accumulation, a function of fluoroquinolone influx versus bacterial efflux
Communications Biology Open Access 28 April 2020
-
Fluoroquinolone structure and translocation flux across bacterial membrane
Scientific Reports Open Access 29 August 2017
-
Microspectrofluorimetry to dissect the permeation of ceftazidime in Gram-negative bacteria
Scientific Reports Open Access 20 April 2017
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Rights and permissions
About this article
Cite this article
The antibacterial lead discovery challenge. Nat Rev Drug Discov 9, 751–752 (2010). https://doi.org/10.1038/nrd3289
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrd3289
This article is cited by
-
The challenge of intracellular antibiotic accumulation, a function of fluoroquinolone influx versus bacterial efflux
Communications Biology (2020)
-
Microspectrofluorimetry to dissect the permeation of ceftazidime in Gram-negative bacteria
Scientific Reports (2017)
-
Fluoroquinolone structure and translocation flux across bacterial membrane
Scientific Reports (2017)
-
Structure–activity relationships of thiostrepton derivatives: implications for rational drug design
Journal of Computer-Aided Molecular Design (2014)
-
Defining a minimum pharmacophore for simocyclinone D8 disruption of DNA gyrase binding to DNA
Medicinal Chemistry Research (2014)