Placing colloidal spheres in the immediate proximity of fluorescent molecules makes it possible to achieve single-molecule imaging at high temperatures with a low-cost system.
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Ebenstein, Y., Bentolila, L. Focusing on the objective. Nature Nanotech 5, 99–100 (2010). https://doi.org/10.1038/nnano.2010.10
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DOI: https://doi.org/10.1038/nnano.2010.10