Medullary thymic epithelial cells maintain tolerance by expressing peripheral self antigens. New data show that they also present these antigens, which leads to the deletion of conventional CD4+ T cells and the induction of regulatory T cells.
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Kim Caesar
References
Klein, L., Hinterberger, M., Wirnsberger, G. & Kyewski, B. Nat. Rev. Immunol. 9, 833–844 (2009).
Anderson, M.S. et al. Science 298, 1395–1401 (2002).
Gray, D., Abramson, J., Benoist, C. & Mathis, D. J. Exp. Med. 204, 2521–2528 (2007).
Hinterberger, M. et al. Nat. Immunol. 11, 512–519 (2010).
van Meerwijk, J.P. et al. J. Exp. Med. 185, 377–383 (1997).
Ohnmacht, C. et al. J. Exp. Med. 206, 549–559 (2009).
Millet, V., Naquet, P. & Guinamard, R.R. Eur. J. Immunol. 38, 1257–1263 (2008).
Liston, A. & Rudensky, A.Y. Curr. Opin. Immunol. 19, 176–185 (2007).
Gallegos, A.M. & Bevan, M.J. J. Exp. Med. 200, 1039–1049 (2004).
Koble, C. & Kyewski, B. J. Exp. Med. 206, 1505–1513 (2009).
Lio, C.W. & Hsieh, C.S. Immunity 28, 100–111 (2008).
Watanabe, N. et al. Nature 436, 1181–1185 (2005).
Bautista, J.L. et al. Nat. Immunol. 10, 610–617 (2009).
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Dzhagalov, I., Robey, E. Multitasking in the medulla. Nat Immunol 11, 461–462 (2010). https://doi.org/10.1038/ni0610-461
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DOI: https://doi.org/10.1038/ni0610-461
