Most insulin-secreting pancreatic β-cells are irreplaceably lost in type 1 diabetes. In a mouse model, pancreatic α-cells seem to sacrifice their identity to replenish the low stock of β-cells1. Two experts discuss what this means for understanding the basic cell biology involved and its relevance to treating diabetes.boxed-text
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Zaret, K., White, M. Extreme makeover of pancreatic α-cells. Nature 464, 1132–1133 (2010). https://doi.org/10.1038/4641132a
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DOI: https://doi.org/10.1038/4641132a