BBLN, a protein with predominantly uncharted functions, serves as an instigator of CAMK2D autophosphorylation, leading to subsequent cardiac remodeling and failure in both humans and mice. The induction of BBLN is driven by hypoxia in TOF and/or pressure overload, as evidenced in mouse models.
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Sperling, S.R. BLN protein induces cardiac hypertrophy and failure. Nat Cardiovasc Res 2, 964–965 (2023). https://doi.org/10.1038/s44161-023-00357-0
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DOI: https://doi.org/10.1038/s44161-023-00357-0