Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Endothelial signaling

Endothelial sensing of dietary metabolites supports barrier tissue homeostasis

Nature Cardiovascular Research volume 2, pages 861–863 (2023)Cite this article

Subjects

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that coordinates cellular responses to environmental stimuli. Two recent Nature papers show that endothelial AHR is responsive to dietary micronutrients, triggering a signaling cascade that supports tissue homeostasis and responses to infection.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: AHR activation in endothelial cells limits inflammation during infection.

References

  1. Guerrina, N. et al. Int. J. Mol. Sci. 19, 3882 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Shi, Z. et al. Front. Immunol. 12, 670632 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Rothhammer, V. & Quintana, F. J. Nat. Rev. Immunol. 19, 184–197 (2019).

    Article  CAS  PubMed  Google Scholar 

  4. Major, J. et al. Nature https://doi.org/10.1038/s41586-023-06287-y (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Wiggins, B. G. et al. Nature https://doi.org/10.1038/s41586-023-06508-4 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Bernier-Latmani, J. et al. Nat. Cardiovasc. Res. 1, 476–490 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Ahmed, S. et al. Toxicol. Sci. 111, 254–266 (2009).

    Article  CAS  PubMed  Google Scholar 

  8. Ohtake, F. et al. Nature 446, 562–566 (2007).

    Article  CAS  PubMed  Google Scholar 

  9. Wang, F. et al. Nucleic Acids Res. 26, 3044–3052 (1998).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

O.A.S. is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and Royal Society (218561/Z/19/Z) and F.K. is supported by the Deutsche Forschungsgemeinschaft (CRC 1450 – 431460824).

Author information

Authors and Affiliations

  1. Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK

    Oliver A. Stone

  2. Institute of Developmental and Regenerative Medicine, University of Oxford, Oxford, UK

    Oliver A. Stone

  3. University of Münster, European Institute for Molecular Imaging, Münster, Germany

    Friedemann Kiefer

Authors
  1. Oliver A. Stone
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Friedemann Kiefer
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Oliver A. Stone or Friedemann Kiefer.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Stone, O.A., Kiefer, F. Endothelial sensing of dietary metabolites supports barrier tissue homeostasis. Nat Cardiovasc Res 2, 861–863 (2023). https://doi.org/10.1038/s44161-023-00341-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s44161-023-00341-8

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing