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Cerebral venous thrombosis (CVT) is a prominent cause of stroke, particularly in young adults. Knowledge of this condition has greatly increased in the past two decades, primarily owing to new data from international patient registries. This Review provides an overview of the epidemiology, pathophysiology, diagnosis and treatment of CVT, with a focus on new advances in the field.
The benefits of aspirin in protecting against thrombotic occlusions are well-established. However, aspirin use has also been linked to increased gastrointestinal and fatal bleeding in elderly patients. Safer preventive approaches should be considered in the elderly population, including reductions in aspirin dose, alternative daily regimens, and individualized treatment strategies.
Revascularization of ischaemia-injured myocardium is critical for functional recovery. A new study shows that endothelial cells of neovessels in the injured heart derive from pre-existing endothelial cells. This new finding focuses research on therapeutic strategies to direct the neovasculature to deliver oxygen and nutrients effectively to the ischaemic myocardium.