Vascular patterning is dictated by transcription factors, such as the Notch pathway. Molecular profiling has uncovered snapshots of the transcriptional specification of endothelial cell tubulogenesis. Here, the authors leverage the output of Notch signaling, demonstrating that vascular remodeling is poorly predicted by transcriptional profiling.
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S.R. is the co-founder and non-paid consultant to the Angiocrine Bioscience, CA. J.M.G-S. declares no competing interests.
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Gomez-Salinero, J.M., Rafii, S. A Notch between vascular morphogenesis and transcriptional identity. Nat Cardiovasc Res 2, 492–493 (2023). https://doi.org/10.1038/s44161-023-00282-2
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DOI: https://doi.org/10.1038/s44161-023-00282-2
