A preactivation-based one-pot glycosylation strategy was used to synthesize RN1 — a polysaccharide comprising 140 monosaccharide units isolated from Panax notoginseng, as well as a glycan fragment library. Evaluation of the biological activity of the glycans in vitro revealed that a decasaccharide fragment shows anti-pancreatic cancer activity.
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References
Zeng, P. & Li, J. et al. The structures and biological functions of polysaccharides from traditional Chinese herbs. Prog. Mol. Biol. Transl Sci. 163, 423–444 (2019). This review discusses the functions of polysaccharides from traditional Chinese herbs.
Wang, P. & Zhang, L. et al. An arabinogalactan from flowers of Panax notoginseng inhibits angiogenesis by BMP2/Smad/Id1 signaling. Carbohydr. Polym. 121, 328–335 (2015). This paper reports the isolation of RN1 from Panax notoginseng and its structural characterization.
Zhang, L. & Wang, P. et al. A novel galectin-3 inhibitor, inhibits pancreatic cancer cell growth in vitro and in vivo via blocking galectin-3 associated signaling pathways. Oncogene 36, 1297–1308 (2017). This paper reports the biological activity of isolated RN1 and the possible mechanism of its anti-pancreatic cancer activity.
Huang, X. & Huang, L. et al. Iterative one-pot synthesis of oligosaccharides. Angew. Chem. Int. Ed. 43, 5221–5224 (2004). This paper reports the preactivation-based one-pot glycosylation strategy that we used herein and demonstrates its application in oligosaccharide assembly.
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This is a summary of: Qin, X. et al. Synthesis of branched arabinogalactans up to a 140-mer from Panax notoginseng and their anti-pancreatic-cancer activity. Nat. Synth. https://doi.org/10.1038/s44160-023-00428-x (2023).
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Synthesis of large polysaccharides facilitates identification of an active glycan domain. Nat. Synth 3, 158–159 (2024). https://doi.org/10.1038/s44160-023-00430-3
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DOI: https://doi.org/10.1038/s44160-023-00430-3
