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ALZHEIMER’S DISEASE

Active immunization in Alzheimer’s disease

Nature Aging volume 1, pages 493–495 (2021)Cite this article

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A phase 2 clinical trial of active immunization against a pathological form of the tau protein provides evidence for feasibility of this approach. Although active treatment did not show benefits on clinical outcome measures, analyses of fluid biomarkers and of a subset of patients with predicted pathology provide hints of efficacy.

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Fig. 1: How tau immunotherapy may counteract pathological tau spread and help its clearance from the brain.

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Authors and Affiliations

  1. Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA

    Douglas Galasko

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  1. Douglas Galasko
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Correspondence to Douglas Galasko.

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The author declares no competing interests.

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Galasko, D. Active immunization in Alzheimer’s disease. Nat Aging 1, 493–495 (2021). https://doi.org/10.1038/s43587-021-00076-w

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