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BRAIN AGING

Unwanted help from T cells in the aging central nervous system

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Groh and colleagues investigate the age-related degeneration of axons in the optic nerve and other brain regions and show that at least part of this degeneration is due to the presence of T cells.

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Fig. 1: Infiltrating cytotoxic CD8+ T cells contribute to axon degeneration in the aging central nervous system in mice.

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Correspondence to Anne Brunet.

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The authors declare no competing interests.

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Navarro Negredo, P., Brunet, A. Unwanted help from T cells in the aging central nervous system. Nat Aging 1, 330–331 (2021). https://doi.org/10.1038/s43587-021-00053-3

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