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Mitochondrial gene editing

Mitochondrial DNA editing with mitoARCUS

Nature Metabolism volume 5, pages 2039–2040 (2023)Cite this article

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The gene-editing tool mitoARCUS has been precisely fine-tuned to reduce m.3243A>G mitochondrial DNA (mtDNA) without harming wild-type mtDNA or nuclear DNA in vitro and in vivo, which paves the road to the first human trials.

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Fig. 1: Mitochondrial gene editing with mitoARCUS.

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Authors and Affiliations

  1. Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK

    Denisa Hathazi & Rita Horvath

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  1. Denisa Hathazi
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  2. Rita Horvath
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Correspondence to Rita Horvath.

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The authors declare no competing interests.

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Hathazi, D., Horvath, R. Mitochondrial DNA editing with mitoARCUS. Nat Metab 5, 2039–2040 (2023). https://doi.org/10.1038/s42255-023-00933-5

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