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T cell metabolism

GLUT2, glucose and oxygen sensing in CD8+ T cells

Nature Metabolism volume 5, pages 1850–1851 (2023)Cite this article

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Glucose transporter-mediated uptake of glucose is a key metabolic checkpoint in T cells. Fu et al. have identified GLUT2 as a critical regulator of CD8+ T cell metabolism and function in response to glucose and oxygen availability.

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Fig. 1: GLUT2 senses glucose and oxygen levels to regulate glucose metabolism and function during CD8+ T cell activation.

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  1. Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Xuemei Tong

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  1. Xuemei Tong
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Correspondence to Xuemei Tong.

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Tong, X. GLUT2, glucose and oxygen sensing in CD8+ T cells. Nat Metab 5, 1850–1851 (2023). https://doi.org/10.1038/s42255-023-00914-8

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