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ADIPOSE TISSUE BIOLOGY

Cellular and molecular brakes on adipogenesis

Nature Metabolism volume 4, pages 13–14 (2022)Cite this article

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De novo adipocyte differentiation ensures healthy adipose tissue expansion and protects against deleterious ectopic lipid deposition in the setting of overnutrition. Dong and Sun et al. identify a molecular brake on adipogenesis that may contribute to the development of insulin resistance in obesity.

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Fig. 1: R-spondin 2 signaling is associated with unhealthy adipose tissue expansion.

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Acknowledgements

The authors are supported by National Institutes of Health NIDDK awards R01 DK104789, RC2 DK118620 and R01 DK119163 to R.K.G.

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  1. Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Jessica Cannavino & Rana K. Gupta

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  1. Jessica Cannavino
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  2. Rana K. Gupta
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Correspondence to Rana K. Gupta.

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The authors declare no competing interests.

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Cannavino, J., Gupta, R.K. Cellular and molecular brakes on adipogenesis. Nat Metab 4, 13–14 (2022). https://doi.org/10.1038/s42255-021-00519-z

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