A study published in this issue of Nature Metabolism adds to the emerging evidence that the small intestine is an initial site of dietary fructose metabolism, especially at low fructose doses, thus decreasing exposure of the liver and the colonic microbiome to intact fructose.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Vos, M. B. et al. Circulation 135, e1017–e1034 (2017).
Stanhope, K. L. et al. J. Clin. Invest. 119, 1322–1334 (2009).
Schwimmer, J. B. et al. J. Am. Med. Assoc. 321, 256–265 (2019).
Van den Berghe, G. Annu. Rev. Nutr. 14, 41–58 (1994).
Jang, C. et al. Cell Metab. 27, 351–361.e3 (2018).
Zhao, S. et al. Nature 579, 586–591 (2020).
Jang, C. et al. Nat. Metab. https://doi.org/10.1038/s42255-020-0222-9 (2020).
Ferraris, R. P., Choe, J. Y. & Patel, C. R. Annu. Rev. Nutr. 38, 41–67 (2018).
Hellerstein, M. K., Schwarz, J. M. & Neese, R. A. Annu. Rev. Nutr. 16, 523–557 (1996).
Smith, G. I. et al. J. Clin. Invest. 130, 1453–1460 (2020).
Lawitz, E. J. et al. Clin. Gastroenterol. Hepatol. 16, 1983–1991.e3 (2018).
Esler, W. P., Tesz, G. J. & Hellerstein, M. K. et al. Sci. Transl. Med. 11, eaau8465 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Hellerstein, M. Surprising findings in a ‘well-understood’ nutrient-assimilation pathway. Nat Metab 2, 561–563 (2020). https://doi.org/10.1038/s42255-020-0242-5
Published:
Issue Date:
DOI: https://doi.org/10.1038/s42255-020-0242-5