Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

DIABETES

Pancreatic β-cell mRNA modification as a marker for type 2 diabetes

Nature Metabolism volume 1, pages 748–749 (2019)Cite this article

Subjects

Diabetes mellitus invariably involves impaired regulation of insulin secretion from pancreatic β cells, as a result of unfavourable environmental influences in combination with aberrant expression of risk genes at either the transcriptional or the translational level. A recent report in Nature Metabolism explores a novel role of mRNA methylation in β-cell function and suggests that its downregulation causes type 2 diabetes.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: A model of the effects of m6A-modulator expression and m6A mRNA methylation in healthy and T2D β-cells.

References

  1. Halban, P. A. et al. Diabetes Care 37, 1751–1758 (2014).

    Article  Google Scholar 

  2. Rorsman, P. & Renström, E. Diabetologia 46, 1029–1045 (2003).

    Article  CAS  Google Scholar 

  3. Shirakawa, J. & Kulkarni, R. N. Diabetes Obes. Metab. 18 Suppl. 1, 71–77 (2016).

  4. Roignant, J. Y. & Soller, M. Trends Genet. 33, 380–390 (2017).

    Article  CAS  Google Scholar 

  5. Liu, J. et al. Nat. Chem. Biol. 10, 93–95 (2014).

    Article  CAS  Google Scholar 

  6. Wang, X. et al. Nature 534, 575–578 (2016).

    Article  CAS  Google Scholar 

  7. De Jesus, D. F. et al. Nat. Metab. https://doi.org/10.1038/s42255-019-0089-9 (2019).

  8. Han, D. et al. Nature 566, 270–274 (2019).

    Article  CAS  Google Scholar 

  9. Liu, J. et al. Nat. Cell Biol. 20, 1074–1083 (2018).

    Article  CAS  Google Scholar 

  10. Geula, S. et al. Science 347, 1002–1006 (2015).

    Article  CAS  Google Scholar 

  11. Lee, H. et al. Nat. Cell Biol. 21, 700–709 (2019).

    Article  CAS  Google Scholar 

  12. Min, K. W. et al. Aging Cell 17, e12753 (2018).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Lund University Diabetes Centre, Exodiab Strategic Research Area in Diabetes, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden

    Erik Renström & Enming Zhang

Authors
  1. Erik Renström
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Enming Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Erik Renström.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Renström, E., Zhang, E. Pancreatic β-cell mRNA modification as a marker for type 2 diabetes. Nat Metab 1, 748–749 (2019). https://doi.org/10.1038/s42255-019-0096-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s42255-019-0096-x

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research