Activation signals from GPCRs, the largest receptor family, are transmitted to heterotrimeric G proteins and arrestins, and can be differentially modulated by GPCR phosphorylation. In a recent article, available data, including multiple arrestin structures, are analyzed to decipher common and state-specific conformational changes in arrestins and how these depend on patterns of receptor phosphorylation.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Fredriksson, R., Lagerström, M. C., Lundin, L. G. & Schiöth, H. B. Mol. Pharmacol. 63, 1256–1272 (2003).
Sente, A. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-018-0071-3 (2018).
Smith, J. S. & Rajagopal, S. J. Biol. Chem. 291, 8969–8977 (2016).
Luttrell, L. M. & Gesty-Palmer, D. Pharmacol. Rev. 62, 305–330 (2010).
Magalhaes, A. C., Dunn, H. & Ferguson, S. S. G. Br. J. Pharmacol. 165, 1717–1736 (2012).
Tobin, A. B., Butcher, A. J. & Kong, K. C. Trends Pharmacol. Sci. 29, 413–420 (2008).
Miller, W. E. & Lefkowitz, R. J. Curr. Opin. Cell Biol. 13, 139–145 (2001).
Kenakin, T. & Christopoulos, A. Nat. Rev. Drug Discov. 12, 205–216 (2013).
Thomsen, A. R. B. et al. Cell 166, 907–919 (2016).
Nobles, K. N. et al. Sci. Signal. 4, ra51 (2011).
Prihandoko, R. et al. Curr. Protoc. Pharmacol. 69, 2.13.1–2.13.26 (2015).
Flock, T. et al. Nature 545, 317–322 (2017).
Gurevich, V. V. & Gurevich, E. V. Int. J. Mol. Sci. 18, 2519 (2017).
Shukla, A. K. et al. Nature 512, 218–222 (2014).
Latorraca, N. R. et al. Nature 557, 452–456 (2018).
Eichel, K. et al. Nature 557, 381–386 (2018).
Honegger, A. & Plückthun, A. J. Mol. Biol. 309, 657–670 (2001).
Brooijmans, N., Chang, Y. W., Mobilio, D., Denny, R. A. & Humblet, C. Protein Sci. 19, 763–774 (2010).
Ballesteros, J. A. & Weinstein, H. in Methods in Neurosciences (ed. Stuart, C.S.) 366–428 (Academic Press, New York, 1995).
Galleni, M. et al. Antimicrob. Agents Chemother. 45, 660–663 (2001).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Draper-Joyce, C.J., Christopoulos, A. Strength in numbers—an arrestin interaction code. Nat Struct Mol Biol 25, 437–439 (2018). https://doi.org/10.1038/s41594-018-0077-x
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41594-018-0077-x
