Computational biology and bioinformatics

Definition

Computational biology and bioinformatics is an interdisciplinary field that develops and applies computational methods to analyse large collections of biological data, such as genetic sequences, cell populations or protein samples, to make new predictions or discover new biology. The computational methods used include analytical methods, mathematical modelling and simulation.

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Latest Research and Reviews

  • Research |

    A new approach to evolve novel aminoacyl-tRNA synthetase–tRNA pairs with orthogonal substrate specificity is applied to generate a system to site-specifically incorporate phosphothreonine into proteins, enabling functional studies of this post-translational modification.

    • Michael Shaofei Zhang
    • , Simon F Brunner
    • , Nicolas Huguenin-Dezot
    • , Alexandria Deliz Liang
    • , Wolfgang H Schmied
    • , Daniel T Rogerson
    •  & Jason W Chin
  • Research |

    Attention changes correlations between neuronal responses. In this study, Verhoef and Maunsell use multielectrode recordings in monkeys to reveal a link between normalization mechanisms, correlated neuronal activity and attention. The findings show that normalization mechanisms shape response correlations and that these correlations change when attention biases normalization mechanisms.

    • Bram-Ernst Verhoef
    •  & John H R Maunsell
  • Research |

    Virus genomes reveal the establishment of Zika virus in Brazil and the Americas, and provide an appropriate timeframe for baseline (pre-Zika) microcephaly in different regions.

    • N. R. Faria
    • , J. Quick
    • , I.M. Claro
    • , J. Thézé
    • , J. G. de Jesus
    • , M. Giovanetti
    • , M. U. G. Kraemer
    • , S. C. Hill
    • , A. Black
    • , A. C. da Costa
    • , L. C. Franco
    • , S. P. Silva
    • , C.-H. Wu
    • , J. Raghwani
    • , S. Cauchemez
    • , L. du Plessis
    • , M. P. Verotti
    • , W. K. de Oliveira
    • , E. H. Carmo
    • , G. E. Coelho
    • , A. C. F. S. Santelli
    • , L. C. Vinhal
    • , C. M. Henriques
    • , J. T. Simpson
    • , M. Loose
    • , K. G. Andersen
    • , N. D. Grubaugh
    • , S. Somasekar
    • , C. Y. Chiu
    • , J. E. Muñoz-Medina
    • , C. R. Gonzalez-Bonilla
    • , C. F. Arias
    • , L. L. Lewis-Ximenez
    • , S. A. Baylis
    • , A. O. Chieppe
    • , S. F. Aguiar
    • , C. A. Fernandes
    • , P. S. Lemos
    • , B. L. S. Nascimento
    • , H. A. O. Monteiro
    • , I. C. Siqueira
    • , M. G. de Queiroz
    • , T. R. de Souza
    • , J. F. Bezerra
    • , M. R. Lemos
    • , G. F. Pereira
    • , D. Loudal
    • , L. C. Moura
    • , R. Dhalia
    • , R. F. França
    • , T. Magalhães
    • , E. T. Marques Jr
    • , T. Jaenisch
    • , G. L. Wallau
    • , M. C. de Lima
    • , V. Nascimento
    • , E. M. de Cerqueira
    • , M. M. de Lima
    • , D. L. Mascarenhas
    • , J. P. Moura Neto
    • , A. S. Levin
    • , T. R. Tozetto-Mendoza
    • , S. N. Fonseca
    • , M. C. Mendes-Correa
    • , F. P. Milagres
    • , A. Segurado
    • , E. C. Holmes
    • , A. Rambaut
    • , T. Bedford
    • , M. R. T. Nunes
    • , E. C. Sabino
    • , L. C. J. Alcantara
    • , N. J. Loman
    •  & O. G. Pybus
  • Research | | open

    IRE1? is an ER stress sensor, whose activity induces apoptosis. Here, the authors report that fortilin, a pro-survival factor, with yet unknown roles in ER stress, interacts with active IRE1?, inhibits both its kinase end RNase activities, and protects cells from apoptosis both in vitro and in vivo.

    • Decha Pinkaew
    • , Abhijnan Chattopadhyay
    • , Matthew D. King
    • , Preedakorn Chunhacha
    • , Zhihe Liu
    • , Heather L. Stevenson
    • , Yanjie Chen
    • , Patuma Sinthujaroen
    • , Owen M. McDougal
    •  & Ken Fujise
  • Research | | open

    Protein-protein interactions (PPIs) play a major role in defining biological functions. Here, the authors present PPiSeq, a method to quantitatively score dynamic PPIs in yeast combining fragment complementation assays, genomic double-barcoding, and an analytical framework to precisely call fitness from barcode lineage trajectories.

    • Ulrich Schlecht
    • , Zhimin Liu
    • , Jamie R. Blundell
    • , Robert P. St.Onge
    •  & Sasha F. Levy

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