A novel approach to probabilistically align adjacent multiple tissue slices from spatially resolved transcriptomics data provides unprecedented depth for the investigation of tissue architecture and paves the way for new developments in 3D spatial analytics.
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References
Zeira, R., Land, M. & Raphael, B. J. Nat. Methods https://doi.org/10.1038/s41592-022-01459-6 (2022).
Rao, A., Barkley, D., França, G. S. & Yanai, I. Nature 596, 211–220 (2021).
Longo, S. K., Guo, M. G., Ji, A. L. & Khavari, P. A. Nat. Rev. Genet. 22, 627–644 (2021).
Biancalani, T. et al. Nat. Methods 18, 1352–1362 (2021).
Bergenstråhle, J., Larsson, L. & Lundeberg, J. BMC Genomics 21, 482 (2020).
Anonymous. Nat. Methods 18, 1 (2021).
Titouan, V., Courty, N., Tavenard, R., Laetitia, C. & Flamary, R. Optimal transport for structured data with application on graphs. in Proc. 36th Int. Conf. Machine Learning 97 (eds Chaudhuri, K. & Salakhutdinov, R.) 6275–6284 (2019).
Rood, J. E. et al. Cell 179, 1455–1467 (2019).
Andersson, A. et al. Preprint at bioRxiv https://doi.org/10.1101/2021.11.11.468178 (2021).
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Lin, Y., Yang, J.Y.H. 3D reconstruction of spatial expression. Nat Methods 19, 526–527 (2022). https://doi.org/10.1038/s41592-022-01476-5
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DOI: https://doi.org/10.1038/s41592-022-01476-5