Data integration

Definition

Data integration is the process of combining data generated using a variety of different research methods in order to enable detection of underlying themes and, in computational biology and bioinformatics, biological principles. Data integration is important in biology owing to the large and different 'omics' datasets now available.

Latest Research and Reviews

  • Research | | open

    Along with various environmental factors, a complex genetic architecture influences human lifespan. Here, McDaid and colleagues reveal novel loci associated with human lifespan and linked biomarkers by Bayesian association scan.

    • Aaron F. McDaid
    • , Peter K. Joshi
    • , Eleonora Porcu
    • , Andrea Komljenovic
    • , Hao Li
    • , Vincenzo Sorrentino
    • , Maria Litovchenko
    • , Roel P. J. Bevers
    • , Sina Rüeger
    • , Alexandre Reymond
    • , Murielle Bochud
    • , Bart Deplancke
    • , Robert W. Williams
    • , Marc Robinson-Rechavi
    • , Fred Paccaud
    • , Valentin Rousson
    • , Johan Auwerx
    • , James F. Wilson
    •  & Zoltán Kutalik
  • Research |

    Longitudinal clinical and multi-omics data from 108 healthy individuals are analyzed to identify putative biomarkers and diagnostics of early disease states.

    • Nathan D Price
    • , Andrew T Magis
    • , John C Earls
    • , Gustavo Glusman
    • , Roie Levy
    • , Christopher Lausted
    • , Daniel T McDonald
    • , Ulrike Kusebauch
    • , Christopher L Moss
    • , Yong Zhou
    • , Shizhen Qin
    • , Robert L Moritz
    • , Kristin Brogaard
    • , Gilbert S Omenn
    • , Jennifer C Lovejoy
    •  & Leroy Hood
  • Research |

    The authors identified a protective genetic allele associated with lower PU.1 (SPI1) expression in myeloid cells by conducting a genome-wide scan of Alzheimer's disease (AD). PU.1 binds the promoters of AD-associated genes (e.g., CD33, MS4A4A & MS4A6A, TYROBP) and modulates their expression, suggesting it may reduce AD risk by regulating myeloid cell gene expression.

    • Kuan-lin Huang
    • , Edoardo Marcora
    • , Anna A Pimenova
    • , Antonio F Di Narzo
    • , Manav Kapoor
    • , Sheng Chih Jin
    • , Oscar Harari
    • , Sarah Bertelsen
    • , Benjamin P Fairfax
    • , Jake Czajkowski
    • , Vincent Chouraki
    • , Benjamin Grenier-Boley
    • , Céline Bellenguez
    • , Yuetiva Deming
    • , Andrew McKenzie
    • , Towfique Raj
    • , Alan E Renton
    • , John Budde
    • , Albert Smith
    • , Annette Fitzpatrick
    • , Joshua C Bis
    • , Anita DeStefano
    • , Hieab H H Adams
    • , M Arfan Ikram
    • , Sven van der Lee
    • , Jorge L Del-Aguila
    • , Maria Victoria Fernandez
    • , Laura Ibañez
    • , The International Genomics of Alzheimer's Project
    • , The Alzheimer's Disease Neuroimaging Initiative
    • , Rebecca Sims
    • , Valentina Escott-Price
    • , Richard Mayeux
    • , Jonathan L Haines
    • , Lindsay A Farrer
    • , Margaret A Pericak-Vance
    • , Jean Charles Lambert
    • , Cornelia van Duijn
    • , Lenore Launer
    • , Sudha Seshadri
    • , Julie Williams
    • , Philippe Amouyel
    • , Gerard D Schellenberg
    • , Bin Zhang
    • , Ingrid Borecki
    • , John S K Kauwe
    • , Carlos Cruchaga
    • , Ke Hao
    •  & Alison M Goate
    Nature Neuroscience 20, 1052–1061

News and Comment