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Cancer immunology

Nurture over nature for old antitumor T cells

Nature Immunology (2024)Cite this article

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How aging, immunity and cancer are related is incompletely understood. Data now show altered differentiation and loss of function of tumor-infiltrating T cells with aging. So-called TTAD cells seem to be involved.

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Fig. 1: Aging promotes T cell-intrinsic and TME-extrinsic defects in antitumor immunity.

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Authors and Affiliations

  1. Department of Immunobiology, University of Arizona College of Medicine–Tucson, Tucson, AZ, USA

    Justin E. Wilson & Janko Ž. Nikolich

  2. University of Arizona Cancer Center, University of Arizona Health Sciences, Tucson, AZ, USA

    Justin E. Wilson & Janko Ž. Nikolich

  3. Arizona Center on Aging, University of Arizona College of Medicine–Tucson, Tucson, AZ, USA

    Janko Ž. Nikolich

  4. Aegis Consortium for Pandemic-free Future, University of Arizona Health Sciences, Tucson, AZ, USA

    Janko Ž. Nikolich

Authors
  1. Justin E. Wilson
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  2. Janko Ž. Nikolich
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Correspondence to Janko Ž. Nikolich.

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The authors declare no competing interest.

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Wilson, J.E., Nikolich, J.Ž. Nurture over nature for old antitumor T cells. Nat Immunol (2024). https://doi.org/10.1038/s41590-024-01853-6

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