Tumour immunology

Definition

Tumour immunology describes the interaction between cells of the immune system with tumour cells. Understanding these interactions is important for the development of new therapies for cancer treatment.

Latest Research and Reviews

  • Research | | open

    • Karla Lucia Fernandez Alvarez
    • , Mariana Beldi
    • , Fabiane Sarmanho
    • , Renata Ariza Marques Rossetti
    • , Caio Raony Farina Silveira
    • , Giana Rabello Mota
    • , Maria Antonieta Andreoli
    • , Eliana Dias de Carvalho Caruso
    • , Marcia Ferreira Kamillos
    • , Ana Marta Souza
    • , Haydee Mastrocalla
    • , Maria Alejandra Clavijo-Salomon
    • , José Alexandre Marzagão Barbuto
    • , Noely Paula Lorenzi
    • , Adhemar Longatto-Filho
    • , Edmund Baracat
    • , Rossana Verónica Mendoza Lopez
    • , Luisa Lina Villa
    • , Maricy Tacla
    •  & Ana Paula Lepique
  • Research |

    Mouse models of breast carcinoma and other solid tumours show that selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors not only induce tumour cell cycle arrest but also promote anti-tumour immunity.

    • Shom Goel
    • , Molly J. DeCristo
    • , April C. Watt
    • , Haley BrinJones
    • , Jaclyn Sceneay
    • , Ben B. Li
    • , Naveed Khan
    • , Jessalyn M. Ubellacker
    • , Shaozhen Xie
    • , Otto Metzger-Filho
    • , Jeremy Hoog
    • , Matthew J. Ellis
    • , Cynthia X. Ma
    • , Susanne Ramm
    • , Ian E. Krop
    • , Eric P. Winer
    • , Thomas M. Roberts
    • , Hye-Jung Kim
    • , Sandra S. McAllister
    •  & Jean J. Zhao
  • Research |

    CMTM6 maintains PD-L1 at the plasma membrane by inhibiting its lysosome-mediated degradation and promoting its recycling.

    • Marian L. Burr
    • , Christina E. Sparbier
    • , Yih-Chih Chan
    • , James C. Williamson
    • , Katherine Woods
    • , Paul A. Beavis
    • , Enid Y. N. Lam
    • , Melissa A. Henderson
    • , Charles C. Bell
    • , Sabine Stolzenburg
    • , Omer Gilan
    • , Stuart Bloor
    • , Tahereh Noori
    • , David W. Morgens
    • , Michael C. Bassik
    • , Paul J. Neeson
    • , Andreas Behren
    • , Phillip K. Darcy
    • , Sarah-Jane Dawson
    • , Ilia Voskoboinik
    • , Joseph A. Trapani
    • , Jonathan Cebon
    • , Paul J. Lehner
    •  & Mark A. Dawson
  • Research | | open

    Grail is an E3 ubiquitin ligase that inhibits T-cell receptor signalling in CD4+ T cells. Here the authors show Grail also limits IL-21 receptor expression and function in CD8+ T cells, is overactive in these cells in patients with lymphoma, and promotes tumour development in a lymphoma transplant mouse model.

    • Cara Haymaker
    • , Yi Yang
    • , Junmei Wang
    • , Qiang Zou
    • , Anupama Sahoo
    • , Andrei Alekseev
    • , Divyendu Singh
    • , Krit Ritthipichai
    • , Yared Hailemichael
    • , Oanh N. Hoang
    • , Hong Qin
    • , Kimberly S. Schluns
    • , Tiejun Wang
    • , Willem W. Overwijk
    • , Shao-Cong Sun
    • , Chantale Bernatchez
    • , Larry W. Kwak
    • , Sattva S. Neelapu
    •  & Roza Nurieva

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