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Leveraging dirty mice that have microbial exposure to improve preclinical models of human immune status and disease

Nature Immunology (2024)Cite this article

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The National Institute of Allergy and Infectious Diseases (NIAID) hosted a two-day virtual workshop on leveraging microbial exposure to improve mouse models of human immune status and disease. The workshop’s objective was to evaluate the current state of knowledge in the field and to identify gaps, challenges and future directions.

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Fig. 1: Immune responses and diseases of microbial experienced humans and mice compared to those of SPF mice.

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Acknowledgements

We thank the invited speakers, and the audience for sharing expertise and stimulating discussions, and reviewing the report. We thank W. Leitner and A. Augustine for editing the report and providing comments. B.R. was supported by the intramural research program of NIDDK, NIH.

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Authors and Affiliations

  1. Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS, Rockville, MD, USA

    Qian Liu, Deborah Hodge, Carmen Rios & Gang Dong

  2. Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS, Rockville, MD, USA

    Thames Pickett & Michelle Arnold

  3. Department of Laboratory Medicine & Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN, USA

    Sara E. Hamilton

  4. Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, MD, USA

    Barbara Rehermann

Authors
  1. Qian Liu
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  2. Thames Pickett
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  3. Deborah Hodge
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  4. Carmen Rios
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  5. Michelle Arnold
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  6. Gang Dong
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  7. Sara E. Hamilton
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  8. Barbara Rehermann
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Corresponding authors

Correspondence to Qian Liu or Barbara Rehermann.

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Competing interests

B.R. discloses that NIDDK granted a license on the WildR mice to Taconic Biosciences and has a Collaborative Research Agreement and Development Award with Genentech. The remaining authors declare no competing interests.

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Liu, Q., Pickett, T., Hodge, D. et al. Leveraging dirty mice that have microbial exposure to improve preclinical models of human immune status and disease. Nat Immunol (2024). https://doi.org/10.1038/s41590-024-01842-9

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