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Immune cell development

Mapping human hematopoiesis

Nature Immunology volume 25, pages 590–591 (2024)Cite this article

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Understanding normal hematopoiesis is critical to understanding disease. Technological advances are driving insight into human hematopoiesis at unprecedented resolution. Integrating ‘-omics’ datasets with machine learning has yielded a high-resolution map of primary human bone marrow hematopoietic progenitor cells that supports the study of immune cell development, as well as the origins of disease.

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Fig. 1: An atlas of normal human hematopoiesis.

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Authors and Affiliations

  1. Division of Pediatric Oncology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Kathrin M. Bernt

  2. Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania and Abramson Cancer Center, Philadelphia, PA, USA

    Kathrin M. Bernt

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  1. Kathrin M. Bernt
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Correspondence to Kathrin M. Bernt.

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Competing interests

K.M.B. declares that they have consulted for Agios and Novartis and have received research funding from Syndax Pharmaceuticals. These contributions are unrelated to the subject material discussed in this article.

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Bernt, K.M. Mapping human hematopoiesis. Nat Immunol 25, 590–591 (2024). https://doi.org/10.1038/s41590-024-01793-1

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