After acute injury to skeletal muscle, an ‘early responder’ subtype of stromal cells rapidly produces an array of inflammatory mediators. Disruption of this response causes abnormal accumulation of several adaptive lymphocyte populations, a prolongation of inflammation, and an effect on tissue regeneration.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Wosczyna, M. N. et al. Mesenchymal stromal cells are required for regeneration and homeostatic maintenance of skeletal muscle. Cell Rep. 27, 2029–2035 (2019). This paper showed that ablation of MmSCs before acute injury led to a notable decrease in accumulation of CD45+ hematopoietic-lineage cells.
Tidball, J. G. Regulation of muscle growth and regeneration by the immune system. Nat. Rev. Immunol. 17, 165–178 (2017). This review highlights key inflammatory mediators produced by CD45+ hematopoietic-lineage cells during acute muscle injury (which are also produced by MmSCs).
Buechler, M. B. et al. Cross-tissue organization of the fibroblast lineage. Nature 593, 575–579 (2021). This paper compares mesenchymal cells across numerous tissues in healthy and diseased states in both mice and humans.
Koliaraki, V., Pradro, A., Armaka, M. & Kolias, G. The mesenchymal context in inflammation, immunity and cancer. Nat. Immunol. 21, 974–982 (2020). This review provides an overview of the contributions of mesenchymal cells in homeostasis and disease.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Yaghi, O. K. et al. A discrete ‘early-responder’ stromal-cell subtype orchestrates immunocyte recruitment to injured tissue. Nat. Immunol. https://doi.org/10.1038/s41590-023-01669-w (2023).
Rights and permissions
About this article
Cite this article
A distinct subtype of stromal cell orchestrates the inflammatory response to tissue injury. Nat Immunol 24, 1976–1977 (2023). https://doi.org/10.1038/s41590-023-01670-3
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-023-01670-3
