Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

CHECKPOINT BLOCKADE

Bidirectional signals of PD-L1 in T cells that fraternize with cancer cells

Nature Immunology volume 21, pages 365–366 (2020)Cite this article

Subjects

PD-L1 expressed by T cells provides backward and forward signals to restrain both innate and adaptive immune responses in tumor tissues.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Bidirectional signaling of PD-L1 expressed by T cells in tumor tissues.

References

  1. Dong, H. & Chen, L. J. Mol. Med. 81, 281–287 (2003).

    Article  CAS  Google Scholar 

  2. Diskin. B. et al. Nat. Immunol. https://doi.org/10.1038/s41590-020-0620-x (2020).

  3. Dong, H., Zhu, G., Tamada, K. & Chen, L. Nat. Med. 5, 1365–1369 (1999).

    Article  CAS  Google Scholar 

  4. Keir, M. E., Butte, M. J., Freeman, G. J. & Sharpe, A. H. Annu. Rev. Immunol. 26, 677–704 (2008).

    Article  CAS  Google Scholar 

  5. Herbst, R. S. et al. Nature 515, 563–567 (2014).

    Article  CAS  Google Scholar 

  6. Tang, H. et al. J. Clin. Invest. 128, 580–588 (2018).

    Article  Google Scholar 

  7. Kamada, T. et al. Proc. Natl Acad. Sci. USA 116, 9999–10008 (2019).

    Article  CAS  Google Scholar 

  8. Pulko, V. et al. J. Immunol. 187, 5606–5614 (2011).

    Article  CAS  Google Scholar 

  9. Dong, H. et al. J. Clin. Invest. 111, 363–370 (2003).

    Article  CAS  Google Scholar 

  10. Saha, A. et al. J. Clin. Invest. 126, 2642–2660 (2016).

    Article  Google Scholar 

  11. Tu, X. et al. Mol. Cell 74, 1215–1226.e4 (2019).

    Article  CAS  Google Scholar 

  12. Chang, C. H. et al. Cell 162, 1229–1241 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biology Discipline, University of Minnesota Morris, Morris, MN, USA

    Rachel M. Gibbons Johnson

  2. Departments of Urology and Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA

    Ti Wen & Haidong Dong

Authors
  1. Rachel M. Gibbons Johnson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ti Wen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Haidong Dong
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Haidong Dong.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Johnson, R.M.G., Wen, T. & Dong, H. Bidirectional signals of PD-L1 in T cells that fraternize with cancer cells. Nat Immunol 21, 365–366 (2020). https://doi.org/10.1038/s41590-020-0599-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-020-0599-3

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer